SIRPA Human
目录号 : GP24587Signal-Regulatory Protein Alpha Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Signal-Regulatory Protein Alpha; SHPS1; CD172Antigen-Like Family Member A; Inhibitory Receptor SHPS-1; Macrophage FusionReceptor; PTPNS1; SIRP; P84; BIT; MFR; Brain-Immunoglobulin-Like Molecule With Tyrosine-BasedActivation Motifs; Brain Ig-Like Molecule With Tyrosine-Based ActivationMotifs; Protein Tyrosine Phosphatase; Non-Receptor Type Substrate 1; Tyrosine-ProteinPhosphatase Non-Receptor Type Substrate 1; Tyrosine Phosphatase SHP Substrate1; Signal-Regulatory Protein Alpha-1 ; ignal-Regulatory Protein Alpha-2; Signal-RegulatoryProtein Alpha-3; SHP Substrate 1; CD172a Antigen; Myd-1 Antigen; MyD-1 Antigen;Sirp-Alpha-1; Sirp-Alpha-2; Sirp-Alpha-3; CD172A; SHPS-1; MYD-1; MYD1; Tyrosine-proteinphosphatase non-receptor type substrate 1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSGVAGEEE LQVIQPDKSV LVAAGETATL RCTATSLIPV GPIQWFRGAGPGRELIYNQK EGHFPRVTTV SDLTKRNNMD FSIRIGNITP ADAGTYYCVK FRKGSPDDVE FKSGAGTELSVRAKPSAPVV SGPAARATPQ HTVSFTCESH GFSPRDITLKWFKNGNELSD FQTNVDPVGE SVSYSIHSTA KVVLTREDVH SQVICEVAHVTLQGDPLRGT ANLSETIRVP PTLEVTQQPV RAENQVNVTC QVRKFYPQRL QLTWLENGNV SRTETASTVTENKDGTYNWM SWLLVNVSAH RDDVKLTCQV EHDGQPAVSK SHDLKVSAHP KEQGSNTAAENTGSNERNIY. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | SIRPA protein solution (0.5mg/ml) containing PBS buffer(pH 7.4), 10% glycerol and 1mM DTT. | ||
Signal-Regulatory Protein Alpha, SIRPA belongs to thesignal-regulatory-protein (SIRP) family, as well as the immunoglobulin super family. The membersof the SIRP family are receptor-typetransmembrane glycoproteins which are involved in the negative regulation of receptor tyrosinekinase-coupled signaling processes. SIRPA can be phosphorylatedby tyrosine kinases. The phospho-tyrosine residues of this PTP have been shownto recruit SH2 domaincontaining tyrosine phosphatases (PTP), and perform as substrates of PTPs. SIRPA take part in signal transduction mediated by a varietyof growth factor receptors. CD47 has been shown to be a ligand for SIRPA.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.