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SM-276001 Sale

目录号 : GC60341

SM-276001 是一种有效的选择性 TLR7 激动剂,可以诱导抗肿瘤免疫反应。SM-276001 是一种具有口服活性的干扰素 (IFN) 诱导剂。

SM-276001 Chemical Structure

Cas No.:473930-22-2

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥2,243.00
现货
5mg
¥2,039.00
现货
10mg
¥3,060.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer[1][2].

SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7[2].

SM-276001 demonstrates potent IFN-inducing activity at a dose of 0.1 mg/kg by oral administration in mice[1]. Oral administration of SM-276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells[2]. SM-276001 (3 mg/kg PO biweekly) significantly inhibits tumor growth in the Renca renal cell cancer and CT26 colorectal models[2]. SM-276001 (orally; 0.1, 1 or 10 mg/kg) leads to the activation of a diverse population of spleen-resident immune effector cells in Balb/c and C57BL/6J mice. When administered at 1 mg/kg or greater, the plasma concentration of SM-276001 exceeds the MEC of 30 nM[2]. Animal Model: C57BL/6 and B6C3F1 mice bearing Renca or CT26 tumors[2]

[1]. Isobe Y, et al. Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers. J Med Chem. 2006 Mar 23;49(6):2088-95. [2]. Koga-Yamakawa E, et al. Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer. Int J Cancer. 2013 Feb 1;132(3):580-90.

化学性质

Cas No. 473930-22-2 SDF
Canonical SMILES NC1=C2C(N(C(N2)=O)CC3=CN=C(C=C3)C)=NC(NCCCC)=N1
分子式 C16H21N7O 分子量 327.38
溶解度 DMSO: 125 mg/mL (381.82 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 3.0546 mL 15.2728 mL 30.5455 mL
5 mM 0.6109 mL 3.0546 mL 6.1091 mL
10 mM 0.3055 mL 1.5273 mL 3.0546 mL
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