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SMIP004 Sale

(Synonyms: N-(4-丁基-2-甲基苯基)乙酰胺,SMIP 004;SMIP-004) 目录号 : GC16055

SMIP004 是一种 SKP2 E3 连接酶抑制剂,可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。

SMIP004 Chemical Structure

Cas No.:143360-00-3

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5mg
¥1,407.00
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10mg
¥2,006.00
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25mg
¥2,877.00
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50mg
¥5,093.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

IC50 Value: 1.09 uM (MTT assay in LNCaP-S14 cells) [1] SMIP004 (N-(4-butyl-2-methyl-phenyl) acetamide) is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells. Unlike SMIP001, SMIP004 was found to downregulate SKP2 and to stabilize p27, although neither SMIP is a proteasome inhibitor. in vitro: Whereas SMIP012 and 016 were moderately toxic in normal fibroblasts, SMIPs 001 and 004 showed substantial cancer cell specificity being at least five times more potent in LNCaP-S14 than in IMR90 cells , treatment with either MG132 or SMIP004 increased p27 half-life to > 6 h [1]. Both SMIP001 and 004 led to a strong increase in the recruitment of p27 to CDK2, while SMIP001 also slightly increased coprecipitation of p21 (Figure 6c). SMIP004 also reduced the amounts of cyclins E and A retrieved with CDK2. This was paralleled by a marked downregulation of cyclins E and A upon SMIP004 treatment. SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors, and resulted in G1 arrest, inhibition of colony formation in soft agar, and cell death [2]. in vivo: SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in mice [2]. Clinical trial: N/A

Chemical Properties

Cas No. 143360-00-3 SDF
别名 N-(4-丁基-2-甲基苯基)乙酰胺,SMIP 004;SMIP-004
化学名 N-(4-butyl-2-methylphenyl)acetamide
Canonical SMILES CCCCC1=CC(=C(C=C1)NC(=O)C)C
分子式 C13H19NO 分子量 205.3
溶解度 ≥ 20.5 mg/mL in DMSO, ≥ 53.6 mg/mL in EtOH with ultrasonic 储存条件 Store at -20°C
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1 mM 4.8709 mL 24.3546 mL 48.7092 mL
5 mM 0.9742 mL 4.8709 mL 9.7418 mL
10 mM 0.4871 mL 2.4355 mL 4.8709 mL
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