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sodium 4-pentynoate Sale

(Synonyms: 4-戊炔酸钠) 目录号 : GC11480

4-戊烯酸钠是一种炔基乙酸类似物,可以通过生物合成机制代谢结合到细胞蛋白上,用于分析不同细胞类型中的乙酰化蛋白。

sodium 4-pentynoate Chemical Structure

Cas No.:101917-30-0

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10mg
¥699.00
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50mg
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100mg
¥3,024.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Sodium 4-pentynoate is an alkynylacetate analogue, which could be incorporated with cellular proteins and utilized as chemical reporter for the profiling of acetylated proteins [1].

Reversible protein acetylation is generally regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), which play important roles in regulating gene expression and occurrence of disease [1].

The p300-KAT-catalyzed acetylation with histone protein H3 showed that the the 4-pentynoate group can be efficiently transferred onto lysine residue. In jurkat cells, metabolic labeling of sodium 4-pentynoate was in time and dose dependent, which was optimal at 2.5-10 μM of acetate analogs for 6-8 hr. Fluorescent profiling identified 194 of 4-pentynoate labeled proteins from jurkat cells, where 86% of them were identified by radioactive method and 14% was newly identified [1].

Reference:
[1].  Yang Y Y, et al. Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc., 2010, 132(11): 3640-3641.

Chemical Properties

Cas No. 101917-30-0 SDF
别名 4-戊炔酸钠
化学名 sodium pent-4-ynoate
Canonical SMILES C#CCCC(=O)[O-].[Na+]
分子式 C5H5NaO2 分子量 120.08
溶解度 H2O : 100 mg/mL (832.78 mM; Need ultrasonic); DMSO : 16.67 mg/mL (138.82 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 8.3278 mL 41.6389 mL 83.2778 mL
5 mM 1.6656 mL 8.3278 mL 16.6556 mL
10 mM 0.8328 mL 4.1639 mL 8.3278 mL
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