Sodium alginate
目录号 : GC67471
Sodium alginate 是海藻酸的钠盐。Sodium alginate 可以从褐藻海带中提取纯化。Sodium alginate 可应用于食品添加剂以及药品，吸附重金属离子并且具有粘膜保护和止血作用。
Cas No.:9005-38-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sodium alginate is the sodium salt of alginic acid. Sodium alginate can be extracted and purified from brown seaweed Laminaria japonica. Sodium alginate can be used in food additives and pharmaceuticals, adsorb heavy metal ions, and has mucosal-protective and hemostatic effects[1][2].
Sodium alginate (0.1-0.5 mL; parietal periosteum, intradermal and subcutaneous injection once) induces granulomatous reactions in rats[1].
| Animal Model: | 8-week-old male Wistar rats[1] |
| Dosage: | 0.1-0.5 mL |
| Administration: | Parietal periosteum, intradermal and subcutaneous injection; 0.2, 0.1 and 0.5 mL respectively, once |
| Result: | Induced macrophages recruitment and generated skin uplift. |
[1]. Mori M, et al. Sodium Alginate as a Potential Therapeutic Filler: An In Vivo Study in Rats. Mar Drugs. 2020 Oct 19;18(10):520.
[2]. Gao X, et al. Adsorption of heavy metal ions by sodium alginate based adsorbent-a review and new perspectives. Int J Biol Macromol. 2020 Dec 1;164:4423-4434.
| Cas No. | 9005-38-3 | SDF | Download SDF |
| 分子式 | C6H9NaO7 | 分子量 | 216.121 |
| 溶解度 | H2O : 6.67 mg/mL (Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.627 mL | 23.1352 mL | 46.2704 mL |
| 5 mM | 0.9254 mL | 4.627 mL | 9.2541 mL |
| 10 mM | 0.4627 mL | 2.3135 mL | 4.627 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Sodium alginate and alginic acid as pharmaceutical excipients for tablet formulation: Structure-function relationship
Carbohydr Polym 2021 Oct 15;270:118399.PMID:34364633DOI:10.1016/j.carbpol.2021.118399.
Alginic acid and its sodium salt are well-accepted pharmaceutical excipients fulfilling several roles in the development of solid oral dosage forms. Although they have attractive advantages as safety, abundance, relatively low cost and biodegradability, these natural polysaccharides possess a high variability that may limit their use as excipients for tablet formulation. Thus, to obtain robust formulations and high-quality drug products with consistent performance a complete understanding of the structure-property relationship becomes necessary as the structure of alginates affects both, technological and biopharmaceutical properties. This review compiles the compaction studies carried out that relate the structure of alginates to their mechanical and dissolution performances. The different analytical methods used to determine the chemical composition, primary structure and molecular weight distribution, major factors affecting the behavior of alginates in direct compression, are also exposed. Finally, different strategies reported to improve the properties of alginic acid as direct compression excipient are discussed.
Sodium alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer
J Pharm Sci 2022 May;111(5):1250-1261.PMID:34986359DOI:10.1016/j.xphs.2021.12.024.
Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as well as low production cost and good availability. One of the most important features typical for alginates is the ability to undergo ionotropic gelation which is gel formation process occurring upon the contact with cations. Because of their advantageous properties, alginates have been extensively utilized in food and pharmaceutical industries. In this review the current knowledge regarding the most recent studies involving both popularly applied dosage forms, like tablets or hydrogels, and novel advanced drug delivery systems applied in targeted therapies are summarized and discussed. The presented studies indicate that although Sodium alginate is a well-established polymer, it is still widely applied as pharmaceutical excipient and the presented research studies indicate that there are still research areas that can be explored and provide innovation in drug delivery systems.
Adsorption of heavy metal ions by Sodium alginate based adsorbent-a review and new perspectives
Int J Biol Macromol 2020 Dec 1;164:4423-4434.PMID:32931827DOI:10.1016/j.ijbiomac.2020.09.046.
With the development of modern industry, heavy metal pollution is one of the most important environmental issues. Due to its simplicity and low-cost, adsorption is considered as a green and environmental friendly method to remove heavy metals from industrial effluents. Sodium alginate is a natural polysaccharide, which consists of abundant hydroxyl and carboxyl groups, has been widely reported as the raw material for the adsorption of heavy metals from aqueous solutions. By surface grafting and cross-linking, adsorbents synthesized from Sodium alginate have exhibited large uptake capacities as well as high removal rates for heavy metal ions. However, the poor physical strength and plain thermostability have significantly limited the utilization of Sodium alginate based materials in industrial applications. Moreover, reductions of specific metal ions were observed in some studies, of which the reduction mechanism is not clearly clarified. In this work, the development of Sodium alginate based adsorbents was summarized, including the physicochemical properties of the polymer, the modification of Sodium alginate, Sodium alginate based composite materials, and the adsorption behaviors as well as the mechanism. Chelation, electrostatic interaction, ion exchange, reduction and photocatalytic reduction were involved in the adsorption process, which can be determined by chemical characterization with further elucidation by density functional theory calculation. Finally, the limitations of Sodium alginate based adsorbents were revealed with suggestions for future research.
Sodium alginate Ultrasound Phantom for Medical Education
Ultrason Imaging 2021 Sep;43(5):253-261.PMID:34036871DOI:10.1177/01617346211018643.
The ultrasound phantoms used to educate medical students should not only closely mimic the ultrasound characteristics of human soft tissues but also be inexpensive and easy to manufacture. I have been studying handmade ultrasound phantoms and proposed an ultrasound phantom comprising calcium alginate hydrogel that met these requirements but caused a speckle pattern similar to that observed in ultrasound images of liver. In this study, I show that adding ethanol to the precursors used to fabricate the phantom reduces the speckle pattern. The ultrasound propagation velocity and attenuation coefficient of the phantom were 1561 ± 8 m/s and 0.54 ± 0.18 dB/cm/MHz, respectively (mean ± standard deviation), which are within the ranges of those in human soft tissues (1530-1600 m/s and 0.3-1.0 dB/cm/MHz, respectively). This phantom is easy to fabricate without special equipment, is inexpensive, and is suitable for elementary training on ultrasound diagnosis, operation of ultrasound-guided needles, and blind catheter insertion.
Sodium alginate-f-GO composite hydrogels for tissue regeneration and antitumor applications
Int J Biol Macromol 2022 May 31;208:475-485.PMID:35318081DOI:10.1016/j.ijbiomac.2022.03.091.
Biopolymer-based composite hydrogels have attracted tremendous attention for tissue regeneration and antitumor applications. Since Sodium alginate is a biopolymer, they offer excellent therapeutic options with long-term drug release and low side effects. To prepare multifunctional composite hydrogels with anticancer and tissue regeneration capabilities, Sodium alginate (SA) and graphene oxide (GO) were covalently linked and crosslinked with tetraethyl orthosilicate (TEOS) by the solvothermal method. The structural and morphological results show that the hydrogels exhibit the desired functionality and porosity. The swelling of hydrogels in an aqueous and PBS medium was investigated. SGT-4 had the highest swelling in both aqueous and PBS media. Swelling and biodegradation of the hydrogel were inversely related. The drug release of SGT-4 was determined in different pH media (pH 6.4, 7.4, and 8.4) and the kinetics of drug release was determined according to the Higuchi model (R2 = 0.93587). Antibacterial activities were evaluated against severe infectious agents. Uppsala (U87) and osteoblast (MC3T3-E1) cell lines were used to determine the anticancer and biocompatibility of the composite hydrogels, respectively. These results suggest that the composite hydrogels could be used as potential biomaterials for tissue regeneration and antitumor applications.