Sodium carboxymethyl cellulose (Viscosity:300-800mpa.s)

Sodium carboxymethyl cellulose (Viscosity:300-800mpa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.

In Vivo, Protocal for preparing 0.5% CMC-Na Solution
Measure 0.5g of dry CMC-Na and dissolved in 100 ml ddH2O/0.9% Saline (0.9 g NaCl in 100 ml ddH2O) to make a clear solution.
Under the condition of stirring and heating (50-65°C), adding CMC-Na slowly to ddH2O/0.9% Saline helps to accelerate dissolution.

Note
1.You must ensure that your CMC-Na solution does not exist solid-liquid separation phenomenon. The solution is in a uniform and transparent state has no particles in it.
2.Completely dissolution of CMC-Na may requires 4 hours or more longer.

In a pharmacological test, CMC-Na (oral;5% in water; 1 year) is well tolerated in rats^[2].
In an acute oral toxicity study in female mice, LD₅₀ of CMC-Na for female mice is 14 g/kg body weight of mice, equivalent to 9.8 g/kg body weight of rat, categorized as practically non-toxic according to Loomis criteria (LD₅₀ 5-15g/kg body weight of rat)^[3].

Sodium carboxymethyl cellulose (Viscosity:300-800mpa.s) 是羧甲基纤维素的钠盐，常用作黏稠剂，糊料和阻隔剂。

在体内，制备 0.5% CMC-Na 溶液的规程
称量 0.5g 干燥的 CMC-Na 并溶解在 100ml ddH2O/0.9% 生理盐水 (0.9g NaCl 溶于 100ml ddH2O) 中制成澄清溶液。
在搅拌和加热 (50-65°C) 条件下，将 CMC-Na 缓慢加入 ddH2O/0.9% Saline 中有助于加速溶解。

注意
1. 您必须确保您的 CMC-Na 溶液不存在固液分离现象。溶液呈均匀透明状态，无颗粒。
2.CMC-Na 完全溶解可能需要 4 小时或更长时间。

在药理试验中，CMC-Na (口服；5% 水溶液；1 年) 在大鼠中具有良好的耐受性^[2]。
在雌性小鼠的急性口服毒性研究中，LD₅₀ 雌性小鼠的 CMC-Na 为 14 g/kg 小鼠体重，相当于 9.8 g/kg 大鼠体重，根据 Loomis 标准 (LD₅₀ 5) 分类为几乎无毒-15g/kg大鼠体重)^[3]。