Sodium copper chlorophyllin
(Synonyms: 叶绿素铜钠) 目录号 : GC32192
叶绿素铜钠对流感病毒和 HIV 具有抗病毒活性，IC50 为 50 至 100 μM 两者。
Cas No.:28302-36-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Sodium copper chlorophyllin exerts antiviral activities against Influenza virus and HIV with IC50s of 50 to 100 μM for both of them.
Sodium copper chlorophyllin exhibits influenza virus adsorption at 200 µM (P<0.05). The 50% inhibitory concentration (IC50) and the 50% cytotoxic concentration (CC50) of Sodium copper chlorophyllin lay from 50 to 100 µM and 200 to 400 µM, respectively. Sodium copper chlorophyllin also inhibits HIV adsorption at 2.5 mM (P<0.05). The IC50 and CC50 of Sodium copper chlorophyllin lay from 50 to 100 µM and 200 to 400 µM, respectively[1].
[1]. Akiko Ito, et al. In Vitro Inhibition of Cytopathic Effect of Influenza Virus and Human Immunodeficiency Virus by Bamboo Leaf Extract Solution and Sodium Copper Chlorophyllin. Yonago Acta Med. 2016 Mar; 59(1): 61-65.
Cell experiment: | MT-2 cells are pre-incubated to the bamboo leaf extract solution (up to 10%), Sodium copper chlorophyllin (up to 5 mM) or test reagent-free culture medium for 10 min to assess the inhibitory activity at adsorption. The pre-incubated cells are washed extensively to be able to eliminate antiviral activity of test reagents remaining in the culture medium, and then they are exposed to HIV-1LAI (1.3×10-4 TCID50 per cell). In addition to these pre-incubated cells, control wells are prepared to evaluate growth of the cells in a virus-free condition. Then, virus-exposed and mock-exposed cells are cultured in the absence of test reagents for three days. The total viable cells are counted on day 3[1]. |
References: [1]. Akiko Ito, et al. In Vitro Inhibition of Cytopathic Effect of Influenza Virus and Human Immunodeficiency Virus by Bamboo Leaf Extract Solution and Sodium Copper Chlorophyllin. Yonago Acta Med. 2016 Mar; 59(1): 61-65. | |
| Cas No. | 28302-36-5 | SDF | |
| 别名 | 叶绿素铜钠 | ||
| Canonical SMILES | [O-]C(CC1=C(C(C([O-])=O)=C(C)C2=CC3=[N]4C(C(C=O)=C3CC)=CC5=C(C=C)C(C)=C6[N-]75)[N-]2[Cu+2]47[N](C8=C6)=C1C(C8C)CCC([O-])=O)=O.[Na+].[Na+].[Na+] | ||
| 分子式 | C34H29CuN4Na3O7 | 分子量 | 738.13 |
| 溶解度 | Water : 10 mg/mL (13.55 mM);DMSO : 6.67 mg/mL (9.04 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3548 mL | 6.7739 mL | 13.5477 mL |
| 5 mM | 0.271 mL | 1.3548 mL | 2.7095 mL |
| 10 mM | 0.1355 mL | 0.6774 mL | 1.3548 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet