Sofalcone
(Synonyms: 索法酮) 目录号 : GC31705
Gastroprotective chalcone derivative
Cas No.:64506-49-6
Sample solution is provided at 25 µL, 10mM.
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Sofalcone is an anti-
1.Kimura, M., Saziki, R., Arai, I., et al.Effect of 2'-carboxymethoxy-4, 4'-bis(3-methyl-2-butenyloxy) chalcone (sofalcone) on chronic gastric ulcers in ratsJpn. J. Pharmacol.35(4)389-396(1984) 2.Suwa, T., Nakazima, M., Shinozaki, A., et al.Cytoprotective effect of SU-88, an anti-ulcer agent, in the ratJpn. J. Pharmacol.3547-53(1984) 3.Tanaka, H., Nakamura, S., Onda, K., et al.Sofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: Implication of heme-oxygenase-1 inductionBiochem. Biophys. Res. Commun.381(4)566-571(2009) 4.Isomoto, H., Furusu, H., Ohnita, K., et al.Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycinWorld J. Gastroenterol.11(11)1629-1633(2005) 5.Higuchi, K., Watanabe, T., Tanigawa, T., et al.Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Heliobacter pylori: A randomized controlled comparative trial with cimetidine, an H2-receptor antagonistJ. Gastroenterol. Hepatol.25S155-S160(2010) 6.Shibuya, A., Onda, K., Kawahara, H., et al.Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cellsBiochem. Biophys. Res. Commun.398(3)581-584(2010)
Cell experiment: | Primary HUVECs are seeded at 60 000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification[1]. |
References: [1]. Onda K, et al. Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. Hypertension. 2015 Apr;65(4):855-62. | |
| Cas No. | 64506-49-6 | SDF | |
| 别名 | 索法酮 | ||
| Canonical SMILES | O=C(O)COC1=CC(OC/C=C(C)/C)=CC=C1C(/C=C/C2=CC=C(OC/C=C(C)/C)C=C2)=O | ||
| 分子式 | C27H30O6 | 分子量 | 450.52 |
| 溶解度 | DMSO : ≥ 100 mg/mL (221.97 mM);Water : < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2197 mL | 11.0983 mL | 22.1966 mL |
| 5 mM | 0.4439 mL | 2.2197 mL | 4.4393 mL |
| 10 mM | 0.222 mL | 1.1098 mL | 2.2197 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet