Sophoraflavanone G
(Synonyms: 槐黄烷酮G,Kushenol F) 目录号 : GC38970A flavonoid with diverse biological activities
Cas No.:97938-30-2
Sample solution is provided at 25 µL, 10mM.
Sophoraflavanone G is a flavonoid that has been found in S. flavescens and has diverse biological activities.1,2,3,4 It is active against 21 strains of methicillin-resistant S. aureus (MRSA; MICs = 3.13-6.25 ?g/ml) and inhibits the activities of α-glucosidase and β-amylase (Kis = 5.6 and 30.6 ?M, respectively).1,2 Sophoraflavanone G is cytotoxic to HL-60 and HepG2 cancer cells (IC50s = 12.5 and 13.3 ?M, respectively) and induces apoptosis in HL-60 cells when used at concentrations of 10 or 25 ?M.3 It reduces LPS-induced production of prostaglandin E2 in RAW 264.7 cells when used at concentrations ranging from 1 to 50 ?M.4 Sophoraflavanone G (250 mg/kg) inhibits carrageenan-induced paw edema in rats.
1.Sato, M., Tsuchiya, H., Takase, I., et al.Antibacterial activity of flavanone isolated from Sophora exigua against methicillin-resistant Staphylococcus aureus and its combination with antibioticsPhytother. Res.9(7)509-512(1995) 2.Kim, J.H., Ryu, Y.B., Kang, N.S., et al.Glycosidase inhibitory flavonoids from Sophora flavescensBiol. Pharm. Bull.29(2)302-305(2006) 3.Ko, W.G., Kang, T.H., Kim, N.Y., et al.Lavandulylfavonoids: A new class of in vitro apoptogenic agents from Sophora favescensToxicol. In Vitro14(5)429-433(2000) 4.Kim, D.W., Chi, Y.S., Son, K.H., et al.Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory responseArch. Pharm. Res.25(3)329-335(2002)
Cas No. | 97938-30-2 | SDF | |
别名 | 槐黄烷酮G,Kushenol F | ||
Canonical SMILES | O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(O)=C13 | ||
分子式 | C25H28O6 | 分子量 | 424.49 |
溶解度 | DMSO: 250 mg/mL (588.94 mM) | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.3558 mL | 11.7788 mL | 23.5577 mL |
5 mM | 0.4712 mL | 2.3558 mL | 4.7115 mL |
10 mM | 0.2356 mL | 1.1779 mL | 2.3558 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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