SPD304

Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.^1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. ^4,5 SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC₅₀ of 22 ?M.⁶ It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC₅₀ of 4.6 ?M.⁶

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