Spexin 1 (human, mouse, rat, bovine) (acetate)
(Synonyms: Neuropeptide Q, NPQ, NWTPQAMLYLKGAQ-NH2, SPX1) 目录号 : GC52390An endogenous peptide and agonist of GAL2 and GAL3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Spexin 1 is an endogenous peptide and agonist of galanin-2 receptor (GAL2) and GAL3.1 It selectively activates GAL2 and GAL3 over GAL1 in HEK293 cells expressing the human receptors and Gαqi (EC50s = 0.161, 0.626, and >10 µM, respectively, in reporter assays). Spexin 1 (50 µg/kg) decreases body weight, fat mass, serum triglyceride levels, and blood glucose and insulin levels in a mouse model of high-fat diet-induced hepatic steatosis.2 Intracerebroventricular administration of spexin 1 (30 nmol/animal) decreases heart rate and urine flow rate, increases mean arterial pressure (MAP) and urinary sodium excretion, and has antinociceptive activity in the warm water tail withdrawal test in rats.3
1.Kim, D.-K., Yun, S., Son, G.H., et al.Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and IIIEndocrinology155(5)1864-1873(2014) 2.Wang, M., Zhu, Z., Kan, Y., et al.Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2Mol. Cell Endocrinol.552111688(2022) 3.Toll, L., Khroyan, T.V., Sonmez, K., et al.Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociceptionFASEB J.26(2)947-954(2011)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.6173 mL | 3.0866 mL | 6.1732 mL |
| 5 mM | 0.1235 mL | 0.6173 mL | 1.2346 mL |
| 10 mM | 0.0617 mL | 0.3087 mL | 0.6173 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。