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Sphingosine-1-phosphate-d7 (d18:1)

(Synonyms: 鞘氨醇-1-磷酸酯-D7(D18:1),S1P-d7 (d18:1), Sphingosine-1-Phosphoric Acid-d7) 目录号 : GC46035

An internal standard for the quantification of S1P

Sphingosine-1-phosphate-d7 (d18:1) Chemical Structure

Cas No.:2260670-15-1

规格 价格 库存 购买数量
500μg
¥5,122.00
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1mg
¥9,217.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Sphingosine-1-phosphate-d7 is intended for use as an internal standard for the quantification of sphingosine-1-phosphate by GC- or LC-MS. S1P is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.[1] It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).[2] Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.[3] S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.

Reference:
[1]. Sanchez, T., and Hla, T. Structural and functional characteristics of S1P receptors. J. Cell. Biochem. 92(5), 913-922 (2004).
[2]. An, S., Bleu, T., and Zheng, Y. Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors. Mol. Pharmacol. 55(5), 787-794 (1999).
[3]. Cartier, A., and Hla, T. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science 366(6463), (2019).

化学性质

Cas No. 2260670-15-1 SDF
别名 鞘氨醇-1-磷酸酯-D7(D18:1),S1P-d7 (d18:1), Sphingosine-1-Phosphoric Acid-d7
化学名 (2S,3R,4E)-2-amino-4-octadecene-16,16,17,17,18,18,18-d7-1,3-diol, 1-(dihydrogen phosphate)
Canonical SMILES O[C@H](/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@@H](N)COP(O)(O)=O
分子式 C18H31D7NO5P 分子量 386.5
溶解度 0.3 M NaOH: 4 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 2.5873 mL 12.9366 mL 25.8732 mL
5 mM 0.5175 mL 2.5873 mL 5.1746 mL
10 mM 0.2587 mL 1.2937 mL 2.5873 mL
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