Sphingosine-d9 (d18:1)
(Synonyms: D-erythro-Sphingosine C18-d9) 目录号 : GC48090A neuropeptide with diverse biological activities
Cas No.:2377379-55-8
Sample solution is provided at 25 µL, 10mM.
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Sphingosine-d9 is intended for use as an internal standard for the quantification of sphingosine by GC- or LC-MS. Sphingosine is formed primarily from the breakdown of ceramide.1 Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.1 Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.2,3,4 [Matreya, LLC. Catalog No. 2079]
1.Hannun, Y.A., Luberto, C., and Argraves, K.M.Enzymes of sphingolipid metabolism: From modular to integrative signalingBiochemistry40(16)4893-4903(2001) 2.Takuwa, Y., Takuwa, N., and Sugimoto, N.The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activitiesJ. Biochem.131(6)767-771(2002) 3.Ishii, I., Fukushima, N., Ye, X., et al.Lysophospholipid receptors: Signaling and biologyAnnu. Rev. Biochem.73321-354(2004) 4.Kluk, M.J., and Hla, T.Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptorsBiochim. Biophys. Acta1582(1-3)72-80(2002)
| Cas No. | 2377379-55-8 | SDF | |
| 别名 | D-erythro-Sphingosine C18-d9 | ||
| Canonical SMILES | OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H] | ||
| 分子式 | C18H28D9NO2 | 分子量 | 308.6 |
| 溶解度 | Chloroform: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2404 mL | 16.2022 mL | 32.4044 mL |
| 5 mM | 0.6481 mL | 3.2404 mL | 6.4809 mL |
| 10 mM | 0.324 mL | 1.6202 mL | 3.2404 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet