Spinosyn A
(Synonyms: 多杀霉素 A) 目录号 : GC16082
A naturally-occurring insecticide
Cas No.:131929-60-7
Sample solution is provided at 25 µL, 10mM.
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Spinosyn A is an insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide.
The spinosyns are a family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa. Spinosyn A is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide.
In vitro: The mixture of spinosyns A and D, a commercial insecticide TracerTM (DowAgroSciences), is useful against various crop pests such as tobacco budworm. It was found that the deoxy analogs of spinosyns A were more potent insecticides than their respective parent factor. Moreover, the 2’-desmethoxy analogs of spinosyns A showed insecticidal potency against H. virescens greater than that of spinosyns A and D, suggesting that polarity was not well tolerated. Furthermore, the activity of 3'-deoxy spinosyn J was about the same as spinosyn A, and the activity of 2'-deoxy spinosyn H was found to be slightly greater than that of spinosyn A [1].
In vivo: Currently, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] L. C. Creemer, H. A. Kirst, J. W. Paschal, et al. Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety. J.Antibiot.(Tokyo) 53(2), 171-178 (2000).
| Cas No. | 131929-60-7 | SDF | |
| 别名 | 多杀霉素 A | ||
| 化学名 | (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3, | ||
| Canonical SMILES | CN(C)[C@H]1CC[C@@](O[C@H]([C@@H](C)C2=O)CCC[C@H](CC)OC(C[C@]3([H])C2=C[C@]4([H])[C@@]3([H])C=C[C@@]5([H])[C@@]4([H])C[C@H](O[C@]6([H])O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]6OC)C5)=O)([H])O[C@@H]1C | ||
| 分子式 | C41H65NO10 | 分子量 | 732.0 |
| 溶解度 | DMSO : 10 mg/mL (13.66 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3661 mL | 6.8306 mL | 13.6612 mL |
| 5 mM | 0.2732 mL | 1.3661 mL | 2.7322 mL |
| 10 mM | 0.1366 mL | 0.6831 mL | 1.3661 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet