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SQ 22536 Sale

(Synonyms: 9-(四氢-2-呋喃)腺膘呤) 目录号 : GC13867

An adenylyl cyclase inhibitor

SQ 22536 Chemical Structure

Cas No.:17318-31-9

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥368.00
现货
10mg
¥630.00
现货
50mg
¥2,436.00
现货

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Sample solution is provided at 25 µL, 10mM.

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SQ22536 is an effective adenylate cyclase (AC) inhibitor.
SQ22536 (SQ22,536) effectively inhibits the effect of forskolin with respective IC50 values of 5 μM.Preincubation with graded concentrations of SQ22536 reveals that both SQ22536 effectively inhibits PACAP-induced reporter gene activation with approximate IC50 value of 5 μM. SQ22536 more potently inhibits forskolin-induced Elk activation (IC50=10 μM) than 8-Br-cAMP-induced Elk activation (IC50=170 μM). Most notably, there are substantial differences in the reported potencies of SQ22536 to inhibit the activities of recombinant AC5 and AC6, with respective IC50 values of 2 μM and 360 μM. At a greater concentration (500 μM), SQ22536 significantly inhibits neurite elongation due to either forskolin or 8-Br-cAMP[1].
Reference:
[1]. Emery AC, et al. A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536. Mol Pharmacol. 2013 Jan;83(1):95-105.

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1 mg 5 mg 10 mg
1 mM 4.8728 mL 24.3641 mL 48.7282 mL
5 mM 0.9746 mL 4.8728 mL 9.7456 mL
10 mM 0.4873 mL 2.4364 mL 4.8728 mL
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