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Squalamine lactate (MSI-1256F) Sale

(Synonyms: MSI-1256F) 目录号 : GC32161

乳酸角鲨胺 (MSI-1256F) 是一种在角鲨组织中发现的氨基甾醇化合物,具有抗菌活性,用于治疗新生血管性年龄相关性黄斑变性。

Squalamine lactate (MSI-1256F) Chemical Structure

Cas No.:320725-47-1

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥11,818.00
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1mg
¥3,938.00
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5mg
¥7,481.00
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10mg
¥12,600.00
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50mg
¥39,375.00
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Sample solution is provided at 25 µL, 10mM.

Description

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].

[1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246. [2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.

化学性质

Cas No. 320725-47-1 SDF
别名 MSI-1256F
Canonical SMILES NCCCCNCCCN[C@H]1CC[C@@]2(C)[C@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CC[C@@H](OS(=O)(O)=O)C(C)C)([H])C1.C[C@@H](C(O)=O)O
分子式 C37H71N3O8S 分子量 718.04
溶解度 DMSO : ≥ 36.66 mg/mL (51.06 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.3927 mL 6.9634 mL 13.9268 mL
5 mM 0.2785 mL 1.3927 mL 2.7854 mL
10 mM 0.1393 mL 0.6963 mL 1.3927 mL
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