SR 12343
目录号 : GC48098
An IKKβ NBD mimetic
Cas No.:2055101-86-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 µM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.
1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018)
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7122 mL | 13.5612 mL | 27.1223 mL |
| 5 mM | 0.5424 mL | 2.7122 mL | 5.4245 mL |
| 10 mM | 0.2712 mL | 1.3561 mL | 2.7122 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。