sRANKL Mouse
目录号 : GP20894RANK 配体可溶性小鼠重组
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Soluble Receptor Activator of NFkB Ligand; TNFSF11; TRANCE; TNF-related activation-induced cytokine; OPGL; ODF; Osteoclast differentiation factor; Tumor necrosis factor ligand superfamily member 11; Receptor activator of nuclear factor kappa B ligand; RANKL; Osteoprotegerin ligand; CD254 antigen; sRANKL; sOdf. | ||
| Amino Acid Sequence | MPAMMEGSWL DVAQRGKPEA QPFAHLTINA ASIPSGSHKV TLSSWYHDRG WAKISNMTLS NGKLRVNQDG FYYLYANICF RHHETSGSVP TDYLQLMVYV VKTSIKIPSS HNLMKGGSTK NWSGNSEFHF YSINVGGFFK LRAGEEISIQ VSNPSLLDPD QDATYFGAFK VQDID. | ||
| Solubility | It is recommended to reconstitute the lyophilized sRANKL in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized TNFSF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution sRANKL should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. | ||
| Biological Activity | Measured by its ability to induce TNF-alpha production in mouse RAW264.7 cells. The ED50 is 48-72ng/ml, corresponding to a specific activity of 2.1x104 Units/mg | ||
| Formulation | The protein (1mg/ml) was lyophilized with 10mM sodium phosphate, pH 7.5 & 20mM NaCl. | ||
RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Measured by its ability to induce TNF-alpha production in mouse RAW264.7 cells. The ED50 is 48-72ng/ml, corresponding to a specific activity of 2.1x104 Units/mg
Lyophilized TNFSF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution sRANKL should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.