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SRI-011381 hydrochloride Sale

目录号 : GC19338

A TGF-β signaling activator

SRI-011381 hydrochloride Chemical Structure

Cas No.:2070014-88-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥420.00
现货
1mg
¥235.00
现货
5mg
¥519.00
现货
10mg
¥897.00
现货
25mg
¥1,862.00
现货
50mg
¥2,993.00
现货
100mg
¥4,851.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

SRI-011381 hydrochloride is a TGF-beta signaling agonist.target: TGF-betaIn vitro: SRI-11381 is neuroprotective. SRI-011381 promot fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.In vivo: SRI-011381 is a biologically active inducer of TGF-β signaling in cell culture and in vivo. SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 (30 mg/kg, dissolved in DMSO) is injected (ip.) into the SBE-luc mice. SRI-011381 is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin. SRI-011381 reduces neurodegeneratio in APP751Lon, Swetransgenic mice.

Reference:
[1]. Benzyl urea derivatives for activating tgf-beta signaling. US 20160039756 A1. 2016. Feb
[2]. Liu Y, et al. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT. Int J Biol Sci. 2018 Oct 31;14(13):1923-1934.

Chemical Properties

Cas No. 2070014-88-7 SDF
Canonical SMILES O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3.Cl[H]
分子式 C20H32ClN3O 分子量 365.94
溶解度 DMSO : 33.33 mg/mL (91.08 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7327 mL 13.6634 mL 27.3269 mL
5 mM 0.5465 mL 2.7327 mL 5.4654 mL
10 mM 0.2733 mL 1.3663 mL 2.7327 mL
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