STAT3 Inhibitor 4m
(Synonyms: Signal Transducer and Activator of Transcription 3 Inhibitor 4m) 目录号 : GC52293
A STAT3 inhibitor
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
STAT3 inhibitor 4m is an inhibitor of STAT3 and a derivative of celastrol .1 It inhibits the phosphorylation of STAT3 and decreases levels of the STAT3 target proteins survivin and myeloid cell leukemia 1 (Mcl-1) in HCT116 cells when used at concentrations of 0.75 and 1 µM. STAT3 inhibitor 4m inhibits the proliferation of A549, HCT116, and HepG2 cells (IC50s = 0.93, 0.61, and 1.79 µM, respectively). It induces apoptosis and cell cycle arrest at both the S and G2/M phases in HCT116 cells when used at a concentration of 5 µM. STAT3 inhibitor 4m (1-10 µM) also reduces the viability of human colorectal cancer organoids (CCOs).
1.Xu, S., Fan, R., Wang, L., et al.Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibitionJ. Enzyme Inhib. Med. Chem.37(1)236-251(2022)
Cas No. | SDF | Download SDF | |
别名 | Signal Transducer and Activator of Transcription 3 Inhibitor 4m | ||
Canonical SMILES | O=C(NCCC1=CC=CS1)[C@]2(C)CC[C@]3(C)CC[C@]4(C)C([C@@]5(C)CC[C@@]4(C)[C@]3([H])C2)=CC=C(C5=C6)C(C)=C(O)C6=O | ||
分子式 | C35H45NO3S | 分子量 | 559.8 |
溶解度 | Chloroform: soluble | 储存条件 | -20°C |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
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1 mg | 5 mg | 10 mg |
1 mM | 1.7864 mL | 8.9318 mL | 17.8635 mL |
5 mM | 0.3573 mL | 1.7864 mL | 3.5727 mL |
10 mM | 0.1786 mL | 0.8932 mL | 1.7864 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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