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Suberosin Sale

(Synonyms: 软木花椒素) 目录号 : GC38984

A prenylated coumarin with diverse biological activities

Suberosin Chemical Structure

Cas No.:581-31-7

规格 价格 库存 购买数量
5mg
¥410.00
现货
10mg
¥693.00
现货
25mg
¥1,386.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Suberosin is a prenylated coumarin that has been found in C. articulata and has diverse biological activities.1,2,3 It inhibits platelet aggregation induced by arachidonic acid , collagen, platelet-activating factor (PAF), adenosine 5'-diphosphate , or U-46619 in washed isolated rabbit platelets (IC50s = 60, 132, 200, 234, and 200 ?M, respectively).2 Suberosin (50 or 100 ?M) reduces arachidonic acid-induced formation of thromboxane B2 in the same model. It inhibits NF-κB nuclear translocation induced by phytohemagglutinin (PHA) in, as well as PHA-induced proliferation of, human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 100 ?M.3

1.Paudel, S., Kim, Y., Choi, S.M., et al.Identification of suberosin metabolites in human liver microsomes by high-performance liquid chromatography combined with high-resolution quadrupole-orbitrap mass spectrometerJ. Mass Spectrom.56(4)e4623(2021) 2.Teng, C.M., Li, H.L., Wu, T.S., et al.Antiplatelet actions of some coumarin compounds isolated from plant sourcesThromb. Res.66(5)549-557(1992) 3.Chen, Y.-C., Tsai, W.-J., Wu, M.-H., et al.Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-κBBr. J. Pharmacol.150(3)298-312(2007)

化学性质

Cas No. 581-31-7 SDF
别名 软木花椒素
Canonical SMILES O=C1C=CC2=CC(C/C=C(C)\C)=C(OC)C=C2O1
分子式 C15H16O3 分子量 244.29
溶解度 DMSO : 100 mg/mL (409.35 mM; Need ultrasonic) 储存条件 4°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.0935 mL 20.4675 mL 40.935 mL
5 mM 0.8187 mL 4.0935 mL 8.187 mL
10 mM 0.4093 mL 2.0467 mL 4.0935 mL
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