Suberosin
(Synonyms: 软木花椒素) 目录号 : GC38984A prenylated coumarin with diverse biological activities
Cas No.:581-31-7
Sample solution is provided at 25 µL, 10mM.
Suberosin is a prenylated coumarin that has been found in C. articulata and has diverse biological activities.1,2,3 It inhibits platelet aggregation induced by arachidonic acid , collagen, platelet-activating factor (PAF), adenosine 5'-diphosphate , or U-46619 in washed isolated rabbit platelets (IC50s = 60, 132, 200, 234, and 200 ?M, respectively).2 Suberosin (50 or 100 ?M) reduces arachidonic acid-induced formation of thromboxane B2 in the same model. It inhibits NF-κB nuclear translocation induced by phytohemagglutinin (PHA) in, as well as PHA-induced proliferation of, human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 100 ?M.3
1.Paudel, S., Kim, Y., Choi, S.M., et al.Identification of suberosin metabolites in human liver microsomes by high-performance liquid chromatography combined with high-resolution quadrupole-orbitrap mass spectrometerJ. Mass Spectrom.56(4)e4623(2021) 2.Teng, C.M., Li, H.L., Wu, T.S., et al.Antiplatelet actions of some coumarin compounds isolated from plant sourcesThromb. Res.66(5)549-557(1992) 3.Chen, Y.-C., Tsai, W.-J., Wu, M.-H., et al.Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-κBBr. J. Pharmacol.150(3)298-312(2007)
Cas No. | 581-31-7 | SDF | |
别名 | 软木花椒素 | ||
Canonical SMILES | O=C1C=CC2=CC(C/C=C(C)\C)=C(OC)C=C2O1 | ||
分子式 | C15H16O3 | 分子量 | 244.29 |
溶解度 | DMSO : 100 mg/mL (409.35 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 4.0935 mL | 20.4675 mL | 40.935 mL |
5 mM | 0.8187 mL | 4.0935 mL | 8.187 mL |
10 mM | 0.4093 mL | 2.0467 mL | 4.0935 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet