Succinylsulfathiazole (Succinylsulphathiazole)
(Synonyms: 琥珀酰磺胺噻唑; Succinylsulphathiazole) 目录号 : GC33943
Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic.
Cas No.:116-43-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic.
| Cas No. | 116-43-8 | SDF | |
| 别名 | 琥珀酰磺胺噻唑; Succinylsulphathiazole | ||
| Canonical SMILES | O=C(O)CCC(NC1=CC=C(S(=O)(NC2=NC=CS2)=O)C=C1)=O | ||
| 分子式 | C13H13N3O5S2 | 分子量 | 355.39 |
| 溶解度 | DMSO : ≥ 3.9 mg/mL (10.97 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8138 mL | 14.0691 mL | 28.1381 mL |
| 5 mM | 0.5628 mL | 2.8138 mL | 5.6276 mL |
| 10 mM | 0.2814 mL | 1.4069 mL | 2.8138 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism
Exp Gerontol 2021 Jul 15;150:111387.PMID:33957263DOI:10.1016/j.exger.2021.111387.
Researchers studying the effect of folate restriction on rodents have resorted to the use of the antibiotic Succinylsulfathiazole (SST) in the folate depleted diet to induce a folate deficient status. SST has been used extensively in rodent studies since the 1940s. Its localized effect on the gut bacteria as well as its effectiveness in reducing folate producing species is well documented. The possible overlap between the pathways affected by folate depletion and SST could potentially produce a confounding variable in such studies. In our novel study, we analyzed the effect of SST on folate levels in c57Bl/6 male mice fed folate supplemented and deficient diets. We did not observe any significant difference on growth and weight gain at 21 weeks. SST did not significantly affect folate levels in the plasma, liver and colon tissues; however, it did alter energy metabolism and expression of key genes in the mTOR signaling pathway in the liver. This research sheds light on a possible confounding element when using SST to study folate depletion due to the potential overlap with multiple critical pathways such as mTOR. SUMMARY: The antibiotic Succinylsulfathiazole (SST) is used to reduce folate producing bacteria in rodent folate depletion studies. SST can modulate critical energy and nutrient sensing pathways converging onto mTOR signaling, and potentially confounding cancer studies.
Biliary excretion of [C]Succinylsulphathiazole in the rat and rabbit
Biochem J 1967 Dec;105(3):1295-9.PMID:16742559DOI:10.1042/bj1051295.
1. After intravenous injection about 30% of the dose (20mg./kg.) of Succinylsulphathiazole is excreted unchanged in the bile in 3hr. by the rat, whereas only about 1% is excreted by the rabbit. When the renal pedicles are ligated the biliary excretion of Succinylsulphathiazole in the rat increases to about 80% of the dose, but in the rabbit under these conditions the biliary excretion is only 2% of the dose. 2. In the rat, the sulphonamide readily enters the liver and biliary excretion occurs against a concentration gradient from liver to bile; further, the excretory process can be saturated, and can be depressed by the simultaneous administration of phenolphthalein glucuronide or bile salts. 3. In the rabbit, these conditions have not been found; Succinylsulphathiazole does not readily enter the liver from the plasma, there is no transfer of the drug from the liver cells to the bile against a concentration gradient, and no saturation or depression of the biliary excretion of Succinylsulphathiazole is found. 4. It is suggested that two factors responsible, at least partly, for the low biliary excretion of Succinylsulphathiazole in the rabbit are the poor entry of the sulphonamide into the liver in this species and a deficiency of the concentrative mechanism for its excretion in the bile.
Succinylsulfathiazole crystal forms. III: Crystal growth studies
J Pharm Sci 1975 Sep;64(9):1485-9.PMID:1185562DOI:10.1002/jps.2600640912.
Crystal growth accompanying the transformation of Succinylsulfathiazole crystal forms in aqueous suspensions was studied using a projecting microscope. The effects of increase of temperature, agitation, inclusion of seeds of Form II (the water-stable dihydrate), sulfathiazole, methylcellulose, and polysorbate 80 on the particle-size distribution of anhydrous Succinylsulfathiazole Form I were examined. Rates of crystal growth, calculated as increase of diameter per unit time, were given under different experimental conditions. Increase of temperature, agitation, and seeding with nuclei of Form II had significant growth-accelerating effects. Sulfathiazole and polysorbate 80 had growth-retarding effects. Methylcellulose inhibited the crystal growth of Form I for over a year. Aqueous suspensions of Form II did not show any change in particle-size distribution. The crystal growth was shown to be a direct consequence of the transformation of the crystal form. Physical conditions and additives which had accelerating or retarding effects on the rate of Succinylsulfathiazole in aqueous suspensions.
Multiple hepatic excretory mechanisms for organic anions. A study with Succinylsulfathiazole and taurocholate in the rat
Can J Physiol Pharmacol 1975 Feb;53(1):97-103.PMID:1139454DOI:10.1139/y75-013.
A study was done to investigate interactions in the biliary excretion of [14-C]Succinylsulfathiazole and [3-H]taurocholate after intravenous administration of the two compounds to anesthetized rats. Either compound administered alone increased bile flow and was excreted in the bile. The simultaneous infusion of both significantly increased bile flow above the values seen when either was given alone. However, the biliary-excretion rates of both compounds and their concentrations in bile were reduced when they were administered concomitantly. The simultaneous injection of radioactive taurocholate and Succinylsulfathiazole did not alter significantly the plasma concentrations of either compound or their binding to plasma proteins from the values obtained when each was given alone. These results are consistent with a concept of competition between these compounds for the same liver-to-bile transport system. They contrast with previous observations that indicated that the concomitant administration of taurocholate increased the biliary excretion of acidic compounds. In the light of this work, it might be suggested that there are more than one transport system for the biliary excretion of organic anions.
Succinylsulfathiazole crystal forms. II: Effect of additives on kinetics of interconversion
J Pharm Sci 1975 Sep;64(9):1481-4.PMID:1185561DOI:10.1002/jps.2600640911.
The effect of various additives on the rate of transformation of the metastable anhydrous Succinylsulfathiazole Form I to the water-stable dihydrate Form II in aqueous suspensions was studied. Some structurally related compounds, viscosity-imparting agents, surfactants, and coloring agents were used as possible transformation retardants. The effect of including seeds of Form II in the presence and absence of additives is also discussed. Some additives, e.g., methylcellulose and phthalysulfathiazole, showed significant transformation-retarding effects. Other additives, e.g., sulfanilamide and glycerin, increased the rate of transformation. Coloring agents had only slight effects. Utilization of the results in the formulation of physically stable aqueous suspensions of Succinylsulfathiazole is discussed.