Sugammadex

Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.¹ It binds rocuronium within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium or atracurium in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.² In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.³

1.de Boer, H.D., van Egmond, J., van de Pol, F., et al.Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkeyBr. J. Anaesth.96(4)473-479(2006) 2.?ahin, H., Toman, H., Kiraz, H.A., et al.Effects of sugammadex on the prevention of postoperative peritoneal adhesionsKaohsiung J. Med. Sci.31(9)463-467(2015) 3.Ozbilgin, S., Yilmaz, O., Ergur, B.U., et al.Effectiveness of sugammadex for cerebral ischemia/reperfusion injuryKaohsiung, J. Med. Sci.32(6)292-301(2016)