Sulcotrione
(Synonyms: 磺草酮) 目录号 : GC30532
Sulcotrione是β-三酮除草剂，可以抑制羟基苯基丙酮酸双加氧酶(HPPD)。
Cas No.:99105-77-8
Sample solution is provided at 25 µL, 10mM.
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Sulcotrione is a β-triketone herbicide which can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).
The results show that sulcotrione behaves as time-independent reversible inhibitor. Similar results are previously described for natural β-triketones, and for the synthetic β-triketone NTBC. However it is the first time that such behavior is observed using a purified hydroxyphenylpyruvate dioxygenase (HPPD) and a synthetic β-triketone, namely sulcotrione. Inhibition kinetic analysis, performing with 3 hydroxyphenylpyruvate (HPP) and sulcotrione concentrations, show that the apparent KM increasing with sulcotrione concentration. This behavior is consistent with the data present in the literature, describing sulcotrione as a competitive inhibitor of HPPD[1].
[1]. Rocaboy-Faquet E, et al. A novel amperometric biosensor for ?-triketone herbicides based on hydroxyphenylpyruvatedioxygenase inhibition: A case study for sulcotrione. Talanta. 2016;146:510-6.
Kinase experiment: | Electrochemical behavior of sulcotrione at 0.2 mg/L is characterized by cyclic voltammetry. Preliminary HPPD inhibition assays are performed by incubating the enzyme during time periods ranging from 2 to 10 min in presence of sulcotrione at differnt concentrations[1]. |
References: [1]. Rocaboy-Faquet E, et al. A novel amperometric biosensor for -triketone herbicides based on hydroxyphenylpyruvatedioxygenase inhibition: A case study for sulcotrione. Talanta. 2016;146:510-6. | |
| Cas No. | 99105-77-8 | SDF | |
| 别名 | 磺草酮 | ||
| Canonical SMILES | O=C(C1C(CCCC1=O)=O)C2=C(C=C(S(C)(=O)=O)C=C2)Cl | ||
| 分子式 | C14H13ClO5S | 分子量 | 328.77 |
| 溶解度 | DMSO : 100 mg/mL (304.16 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0416 mL | 15.2082 mL | 30.4164 mL |
| 5 mM | 0.6083 mL | 3.0416 mL | 6.0833 mL |
| 10 mM | 0.3042 mL | 1.5208 mL | 3.0416 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet