Sulfacarbamide
(Synonyms: 磺胺脲) 目录号 : GC32513
Sulfacarbamide是一种降血糖药物,也作用于植物神经系统。
Cas No.:547-44-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sulfacarbamide is a blood sugar-lowering drug, also acting on the vegetative nervous system.
| Cas No. | 547-44-4 | SDF | |
| 别名 | 磺胺脲 | ||
| Canonical SMILES | O=S(C1=CC=C(N)C=C1)(NC(N)=O)=O | ||
| 分子式 | C7H9N3O3S | 分子量 | 215.23 |
| 溶解度 | DMSO : ≥ 28 mg/mL (130.09 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.6462 mL | 23.231 mL | 46.4619 mL |
| 5 mM | 0.9292 mL | 4.6462 mL | 9.2924 mL |
| 10 mM | 0.4646 mL | 2.3231 mL | 4.6462 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The comprehensive effects of aluminum oxide nanoparticles on the physiology of freshwater microalga Scenedesmus obliquus and it's phycoremediation performance for the removal of sulfacetamide
Environ Res 2022 Dec;215(Pt 2):114314.PMID:36116497DOI:10.1016/j.envres.2022.114314.
Nanoparticles are inevitable byproducts of modern industry. However, the environmental impacts arising from industrial applications of nanoparticles are largely under-reported. This study evaluated the ecotoxicological effects of aluminum oxide nanoparticles (Al2O3NP) and its influence on sulfacetamide (SA) biodegradation by a freshwater microalga, Scenedesmus obliquus. Although Al2O3NP showed limited toxicity effect on S. obliquus, we observed the toxicity attenuation aspect of Al2O3NP in a mixture of sulfacetamide on microalgae. The addition of 100 mg L-1 of Al2O3NP and 1 mg L-1 of SA reduced total chlorophyll by 23.3% and carotenoids by 21.6% in microalgal compared to control. The gene expression study demonstrated that ATPF0C, Lhcb1, HydA, and psbA genes responsible for ATP synthesis and the photosynthetic system were significantly downregulated, while the Tas gene, which plays a major role in biodegradation of organic xenobiotic chemicals, was significantly upregulated at 1 and 100 mg L-1 of Al2O3NP. The S. obliquus removed 16.8% of SA at 15 mg L-1 in 14 days. However, the removal was slightly enhanced (18.8%) at same concentration of SA in the presence of 50 mg L-1 Al2O3NP. This result proves the stability of sulfacetamide biodegradation capacity of S. obliquus in the presence of Al2O3NP co-contamination. The metabolic analysis showed that SA was degraded into simpler byproducts such as Sulfacarbamide, sulfaguanidine, sulfanilamide, 4-(methyl sulfonyl)aniline, and N-hydroxy-benzenamine which have lower ecotoxicity than SA, demonstrating that the ecotoxicity of sulfacetamide has significantly decreased after the microalgal degradation, suggesting the environmental feasibility of microalgae-mediated wastewater technology. This study provides a deeper understanding of the impact of nanoparticles such as Al2O3NP on aquatic ecosystems.
Sulfonamide and trimethoprim concentrations in human serum and skin blister fluid
Antimicrob Agents Chemother 1981 Jan;19(1):82-5.PMID:7247364DOI:10.1128/AAC.19.1.82.
Various sulfonamides and trimethoprim were given orally twice a day to healthy volunteers. The drug concentrations in serum and tissue fluid from skin blisters were determined concomitantly. Maximal serum concentrations were obtained after 1 to 3 h. Absorption of Sulfacarbamide and sulfadimidine was more rapid than for sulfadiazine, sulfamethoxazole, and trimethoprim. The penetration to blister fluid was delayed and maximal concentrations were usually reached after 4 to 8 h. The highest penetration to blister fluid was found for Sulfacarbamide, sulfadiazine, and trimethoprim. During maintenance therapy sulfadiazine and trimethoprim gave blister fluid concentrations usually above 50% of the serum level. However, on the basis of dosage the highest sulfonamide concentration both in serum and blister fluid was obtained with sulfamethoxazole.
Optimization and validation of the micellar electrokinetic capillary chromatographic method for simultaneous determination of sulfonamide and amphenicol-type drugs in poultry tissue
J Pharm Biomed Anal 2011 Jan 5;54(1):160-7.PMID:20817447DOI:10.1016/j.jpba.2010.08.005.
The report describes a new approach enabling simple and rapid multi-residue screening of seven sulfonamides (SAs): sulfamethazine (SMZ), sulfamerazine (SMR), sulfathiazole (STZ), sulfachloropyridazine (SCP), sulfamethoxazole (SMX), Sulfacarbamide (SC), and sulfaguanidine (SG); and three amphenicol-type antibiotics: chloramphenicol (CAP), thiamphenicol (TAP), and florfenicol (FF) in animal tissue by micellar electrokinetic chromatography (MEKC). The analytes were isolated from tissue samples through solid-phase extraction (with a C(18) cartridges) following protein precipitation with acetonitrile. The evaluated LOD and LOQ values ranged from 1.3 to 7.8 and from 4.5 to 26.1 ng/g, respectively. These values are far lower than the maximum residue limits (MRLs) set by several control authorities. Intra- and inter-day precision data were less than 9.5% and 11.2% for SAs, and 8.4% and 14.9% for amphenicols. Moreover, the method was found accurate, with the recoveries ranging from 86.4% to 109.4%. The absolute recoveries of the analysed drugs were higher than 77.2%. The results obtained in the validation process demonstrate that the developed CE method is suitable for simultaneous determination of SA and amphenicol residues in poultry tissue, with the total run time less than 8 min.
Human pharmacokinetics and skin blister levels of sulfonamides and dihydrofolate reductase inhibitors
Chemotherapy 1986;32(4):319-28.PMID:3731918DOI:10.1159/000238430.
The penetration into suction skin blisters and pharmacokinetics of 4 sulfonamides (Sulfacarbamide, sulfadimidine, sulfadiazine, sulfamethoxazole) and two dihydrofolate reductase inhibitors (methioprim, trimethoprim) have been compared in healthy volunteers. The concentrations were monitored after the first dose and for the subsequent 4 days when approximate steady state conditions could be assumed to have been established. The serum or plasma half-life of the agents in the above order was 3.1, 6.3, 13.9, 12.1, 9.3, and 12.0 h. The respective areas under the serum curves were 97.1, 607.8, 942.6, 1423.1, 128.1 and 175.4 mg/l per dose of 1.0 g. With the sulfonamides, there was a distinct correlation between serum protein binding and pKa and the ability of the compounds to penetrate into blister fluid as shown by the 12-hour ratios between areas under the concentration curves in blister fluid relative to serum.