Sulfachloropyridazine (Sulfachlorpyridazine)
(Synonyms: 磺胺氯哒嗪; Sulfachlorpyridazine) 目录号 : GC32395
Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections.
Cas No.:80-32-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections.
| Cas No. | 80-32-0 | SDF | |
| 别名 | 磺胺氯哒嗪; Sulfachlorpyridazine | ||
| Canonical SMILES | O=S(C1=CC=C(N)C=C1)(NC2=NN=C(Cl)C=C2)=O | ||
| 分子式 | C10H9ClN4O2S | 分子量 | 284.72 |
| 溶解度 | DMSO : 160 mg/mL (561.96 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5122 mL | 17.5611 mL | 35.1222 mL |
| 5 mM | 0.7024 mL | 3.5122 mL | 7.0244 mL |
| 10 mM | 0.3512 mL | 1.7561 mL | 3.5122 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Determination of Sulfachloropyridazine residue levels in feathers from broiler chickens after oral administration using liquid chromatography coupled to tandem mass spectrometry
PLoS One 2018 Jul 5;13(7):e0200206.PMID:29975750DOI:10.1371/journal.pone.0200206.
Several antimicrobials are routinely used by the poultry farming industry on their daily operations, however, researchers have found for some antimicrobials that their residues persist for longer periods in feathers than they do in edible tissues, and at higher concentrations, as well. But this information is not known for other classes of antimicrobials, such as the sulfonamides. Therefore, this work presents an accurate and reliable analytical method for the detection of Sulfachloropyridazine (SCP) in feathers and edible tissues from broiler chickens. This method was also validated in-house and then used to study the depletion of Sulfachloropyridazine in those matrices. The experimental group comprised 54 broiler chickens, who were raised under controlled conditions and then treated with a commercial formulation of 10% Sulfachloropyridazine for 5 days. Samples were analyzed via LC-MS/MS, using 13C6-sulfamethazine (SMZ-13C6) as an internal standard. Aromatic sulfonic acid solid phase extraction (SPE) cartridges were used to clean up the samples. The Limit of Detection (LOD) for this method was set at 10 渭g kg-1 on feathers and liver; and at 5 渭g kg-1 on muscle. Within the range of 10-100 渭g kg-1, the calibration curves for all matrices presented a determination coefficient greater than 0.96. Our results show, with a 95% confidence level, that Sulfachloropyridazine persisted in feathers for up to 55 days after ceasing treatment, and its concentrations were higher than in edible tissues. In consequence, to avoid re-entry of antimicrobial residues into the food-chain, we recommend monitoring and inspecting animal diets that contain feather derivatives, such as feathers meals, because they could be sourced from birds that might have been medicated with Sulfachloropyridazine.
Effects of ethanamizuril, Sulfachlorpyridazine or their combination on cecum microbial community and metabolomics in chickens infected with Eimeria tenella
Microb Pathog 2022 Dec;173(Pt A):105823.PMID:36243384DOI:10.1016/j.micpath.2022.105823.
Coccidiostat and antibiotics are widely used in poultry industry, but their effects on cecum microbial community and metabolomics in chickens infected with coccidia have been rarely studied. In this study, we analyzed the changes of microbiota and metabolomic which associated with Eimeria tenella infection in 8 days of age chickens in the presence or absence of ethanamizuril, Sulfachlorpyridazine or their combinations treatment for 3 consecutive days. 16S rRNA gene sequencing and LC-MS/MS analyses were used to profile the cecal microbiome and metabolome in each group of chickens on 7 days post-infection. The results showed that coccidial infection induced significant perturbations in the distribution of microbial taxonomy and the metabolism of physiological functional molecules in cecal contents. Ethanamizuril treatment seemed to transform microbiota into a steady state conducive to animal health, and Sulfachlorpyridazine treatment alleviated the growth of potentially harmful bacteria such as Escherichia-Shigella. The change trends of metabolites such as n-carbamoylglutamic acid were consistent with the anticoccidial effect of ethanamizuril. The combinations of ethanamizuril and Sulfachlorpyridazine at low-dose had little effect on gut microbiota, metabolism and anticoccidial effect. These data indicate that the cecal microbiota and metabolic status of chickens infected with E. tenella following ethanamizuril treatment could be used to monitor the response to drug efficacy. This study provides a new system approach to elucidate the microbiota, metabolic and therapeutic effects of the combination of coccidiostat and antibiotics in the context of avian coccidiosis.
WS2 significantly enhances the degradation of Sulfachloropyridazine by Fe(III)/persulfate
Sci Total Environ 2022 Dec 1;850:157987.PMID:35964753DOI:10.1016/j.scitotenv.2022.157987.
The use of antibiotics has become an indispensable part of the production and life of human society. Among them, sulfonamide antibiotics widely used in humans and animals are considered to be one of the most crucial antibiotics. However, antibiotics are difficult to degrade naturally, leading to an accumulation in the environment and a potential hazard to human health. In this paper, WS2 as a co-catalyst could reduce trace Fe(III) to Fe(II) which exhibited a great activating ability to PS through the exposed W(IV) active sites, and formed the Fe(III)/Fe(II) cycle to degrade Sulfachloropyridazine (SCP) continuously. This paper systematically discussed the degradation of SCP under different conditions in the PS/WS2/Fe(III) system, including the amount of WS2, Fe(III) concentration, PS concentration, initial pH, natural organic matter (NOM) and common anions (NO3-, Cl-, HCO3-, HPO42- and H2PO4-). The experimental results showed that PS/WS2/Fe(III) system possessed a strong degradation ability for SCP in a wide pH range. NO3- and Cl- could promote the degradation of SCP a little. HCO3-, HPO42- and H2PO4- could significantly inhibit the degradation of SCP. The main types of free radicals that degraded SCP were explored. In addition, the stability and reusability of WS2 were examined, and two possible degradation pathways of SCP were proposed.
Catalytic oxidation of Sulfachloropyridazine by MnO2: Effects of crystalline phase and peroxide oxidants
Chemosphere 2021 Mar;267:129287.PMID:33348268DOI:10.1016/j.chemosphere.2020.129287.
Catalytic activation of different oxidants including peroxymonosulfate (PMS), peroxydisulfate (PDS), hydrogen peroxide (H2O2) and ozone (O3) by MnO2 for degradation of Sulfachloropyridazine (SCP) was investigated and the effects of different crystalline phases of MnO2 including nanowire 伪-MnO2, nanorod 尾-MnO2, nanofiber 纬-MnO2, and nanosphere 未-MnO2 on catalytic ozonation of SCP were also studied. The SCP degradation and total organic carbon removal indicated that the oxidation efficiency of the peroxide oxidants followed an order of O3/MnO2 > PMS/MnO2 > PDS/MnO2 > H2O2/MnO2. In catalytic ozonation, SCP degradation rate constants of different MnO2 phases followed an order of 未-MnO2 > 伪-MnO2 > 纬-MnO2> 尾-MnO2. Electron paramagnetic resonance (EPR) suggested that hydroxyl radicals (路OH) and singlet oxygen (1O2) might be more significant for SCP degradation than sulfate (SO4路-) and superoxide (路O2-) radicals. Radical competition experiments demonstrated that 1O2 and 路OH contributed to 63.16% and 28.07%, respectively, for the catalytic ozonation of SCP. It was also found that more oxygen vacancies, specific surface area and exposure of MnO6 edges could facilitate the activation of O3 for 1O2 and 路OH productions and SCP degradation. The degradation pathways of SCP could mainly follow the cleavage of S-C or S-N bond and dechlorination, accompanied by hydroxylation and oxidation.
Relationships between Sulfachloropyridazine sodium, zinc, and sulfonamide resistance genes during the anaerobic digestion of swine manure
Bioresour Technol 2017 Feb;225:343-348.PMID:27912183DOI:10.1016/j.biortech.2016.10.057.
In this study, swine manure containing Sulfachloropyridazine sodium (SCPS) and zinc was subjected to mesophilic (37掳C) anaerobic digestion (AD). The absolute abundances (AAs) of antibiotic resistance genes (ARGs) were evaluated, as well as intI1 and intI2, and the degradation of SCPS according to variation in the amount of bio-available zinc (bio-Zn). In digester that only contained SCPS, the concentrations of SCPS were lower than that digesters both contain SCPS and Zn. Compared with the control digester, the addition of SCPS increased the AAs of sul1, sul3, drfA1, and drfA7 by 1.3-13.1 times. However, compared with the digester with SCPS but no added Zn, the AAs of sul3, drfA1, and drfA7 were decreased by 21.4-70.3% in the presence of SCPS and Zn, whereas sul1 and sul2 increased 1.3-10.7 times. There were significant positive correlations (P<0.05) between the concentrations of SCPS with several ARGs and bio-Zn.