Sulfadimethoxine sodium
(Synonyms: 磺胺间二甲氧嘧啶钠,Sulphadimethoxine sodium) 目录号 : GC61301
A sulfonamide antibiotic
Cas No.:1037-50-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms.1 It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay.2 Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay.1 It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml).3,4 Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).1
1.B?hni, E., Fust, B., Rieder, J., et al.Comparative toxicological, chemotherapeutic and pharmacokinetic studies with sulphormethoxine and other sulphonamides in animals and manChemotherapy14(4)195-226(1969) 2.Hong, Y.-L., Hossler, P.A., Calhoun, D.H., et al.Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugsAntimicrob. Agents Chemother.39(8)1756-1763(1995) 3.Agnoletti, F., Ferro, T., Guolo, A., et al.A survey of Clostridium spiroforme antimicrobial susceptibility in rabbit breedingVet. Microbiol.136(1-2)188-191(2009) 4.Angelos, J.A., Ball, L.M., and Byrne, B.A.Minimum inhibitory concentrations of selected antimicrobial agents for Moraxella bovoculi associated with infectious bovine keratoconjunctivitisJ. Vet. Diagn. Invest.23(3)552-555(2011)
| Cas No. | 1037-50-9 | SDF | |
| 别名 | 磺胺间二甲氧嘧啶钠,Sulphadimethoxine sodium | ||
| Canonical SMILES | O=S(C1=CC=C(N)C=C1)(N([Na])C2=NC(OC)=NC(OC)=C2)=O | ||
| 分子式 | C12H13N4NaO4S | 分子量 | 332.31 |
| 溶解度 | DMSO: 250 mg/mL (752.31 mM) | 储存条件 | 4°C, away from moisture and light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0092 mL | 15.0462 mL | 30.0924 mL |
| 5 mM | 0.6018 mL | 3.0092 mL | 6.0185 mL |
| 10 mM | 0.3009 mL | 1.5046 mL | 3.0092 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Trimethoprim and Sulfadimethoxine sodium in Oral Liquid Dosage Form
Sci Pharm 2013 Apr-Jun;81(2):459-74.PMID:23833713DOI:10.3797/scipharm.1212-30.
A simple, specific, accurate, and stability-indicating RP-HPLC method was developed and validated for the simultaneous determination of Trimethoprim (TMP) and Sulfadimethoxine sodium (SDMS) in Vetricine(®) oral solution product. The desired separation was achieved on an ODS column (250×4.6 mm i.d., 5 μm) at room temperature. The optimized mobile phase consisted of an isocratic solvent mixture of water:acetonitrile:triethylamine (700:299:1, v/v/v), adjusted to a pH of 5.7 ± 0.05 with 0.2N acetic acid. The mobile phase was fixed at 0.8 ml/min and the analytes were monitored at 254 nm using a photodiode array detector. The effects of the chromatographic conditions on the peaks USP tailing factor, column efficiency, and resolution were systematically optimized. Forced degradation experiments were carried out by exposing TMP, SDMS standards, and the oral solution formulation to thermal, photolytic, oxidative, and acid-base hydrolytic stress conditions. The degradation products were well-resolved from the main peaks and the excipients, thus proving the reliable stability-indicating method. The method was validated as per ICH and USP guidelines (USP34/NF29) and found to be adequate for the routine quantitative estimation of TMP and SDMS in commercially available Vetricine® oral liquid dosage form.
Influence of metal ions on sulfonamide antibiotics biochemical behavior in fiber coexisting system
J Environ Sci (China) 2019 Jun;80:267-276.PMID:30952344DOI:10.1016/j.jes.2019.01.003.
Metal ions and fiber are common compounds in the livestock and poultry manure, which will affect the fate of organic compounds in aqueous environment. However, limited research has addressed the effect of coexisting metal ions and fiber on the biodegradation of sulfonamide antibiotics. Accordingly, a compositing study was performed to assess the effect of metal ions (Fe3+ and Cu2+) on the biodegradation of Sulfadimethoxine sodium salt (SDM) in the presence of fiber. The enhanced adsorption of SDM onto fiber in the presence of metal ions can be attributed to the π+-π electron donor acceptor (EDA) interaction. The microbial (Phanerochaete chrysosprium) could easily attach onto fiber forming attached microbial, and the degradation rates of SDM of immobilized bacteria in the presence of Fe3+ were 100%, which were significantly higher than those of free bacteria (45%). This study indicates that Fe3+ and fiber could enhance the biodegradation of SDM. Fiber acts as adsorbent, carrier, and substrate which enhanced the removal of SDM.