Sulfanilic Acid
(Synonyms: 对氨基苯磺酸) 目录号 : GC48945
A synthetic intermediate
Cas No.:121-57-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sulfanilic acid is a synthetic intermediate.1,2 It has been used in the synthesis of activated carbon for biodiesel preparation, as well as various nanocomposites.
1.Malins, K., Kampars, V., Brinks, J., et al.Synthesis of activated carbon based heterogenous acid catalyst for biodiesel preparationAppl. Catal. B-Environ.176-177553-558(2015) 2.Zhang, L., Shi, T., Wu, S., et al.Sulfonated graphene oxide: The new and effective material for synthesis of polystyrene-based nanocompositesColloid Polym. Sci.291(9)2061-2068(2013)
| Cas No. | 121-57-3 | SDF | |
| 别名 | 对氨基苯磺酸 | ||
| Canonical SMILES | O=S(O)(C1=CC=C(C=C1)N)=O | ||
| 分子式 | C6H7NO3S | 分子量 | 173.2 |
| 溶解度 | DMF: 1 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml | 储存条件 | Store at -20°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.7737 mL | 28.8684 mL | 57.7367 mL |
| 5 mM | 1.1547 mL | 5.7737 mL | 11.5473 mL |
| 10 mM | 0.5774 mL | 2.8868 mL | 5.7737 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Sulfanilic Acid increases intracellular free-calcium concentration, induces reactive oxygen species production and impairs trypsin secretion in pancreatic AR42J cells
Food Chem Toxicol 2018 Oct;120:71-80.PMID:29986830DOI:10.1016/j.fct.2018.07.001.
We studied the effects of the tartrazine-metabolite Sulfanilic Acid on the physiology of pancreatic AR42J cells. Sulfanilic Acid (1 μM-1 mM) induced a slow and progressive increase in intracellular free-calcium concentration that reached a plateau. The effect of Sulfanilic Acid was not concentration-dependent. Stimulation of cells with thapsigargin (1 μM) after treatment with Sulfanilic Acid (1 mM) induced a smaller Ca2+ response compared with that obtained with thapsigargin alone. Sulfanilic Acid induced a concentration-dependent production of reactive oxygen species; however, this effect was not Ca2+-dependent. Depolarization of mitochondrial membrane potential was observed at the concentration of 1 mM Sulfanilic Acid. In the presence of the compound a decrease in the GSH/GSSG ratio was observed. A decrease in the expression of superoxide dismutase 2 was noted. Finally, stimulation of cells with CCK-8 led to a concentration-dependent increase of trypsin secretion that was impaired by pretreatment of cells with Sulfanilic Acid. Preincubation of cells with the antioxidant melatonin (100 μM) reduced the effect of Sulfanilic Acid on trypsin secretion. We conclude that Sulfanilic Acid might induce oxidative stress, which could alter Ca2+ signaling and enzyme secretion in pancreatic AR42J cells. This creates a situation potentially leading to damage of the exocrine pancreas.
The ephemeral dihydrate of Sulfanilic Acid
Acta Crystallogr C Struct Chem 2018 Jan 1;74(Pt 1):7-12.PMID:29303491DOI:10.1107/S2053229617016886.
Evaporation of an aqueous solution of Sulfanilic Acid (systematic name: 4-aminobenzene-1-sulfonic acid) at 273 K affords a crystalline dihydrate, C6H7NO3S·2H2O. The organic molecule exists as a zwitterion; two zwitterions are aligned in an antiparallel fashion about a crystallographic centre of inversion. They interact directly via two N-H...O hydrogen bonds between the ammonium group of one zwitterion and the sulfonate group of its symmetry-related counterpart, and their aromatic rings are π-stacked, with an interplanar distance of 3.533 (3) Å. One of the cocrystallized water molecules connects the resulting pairs into layers and the second crosslinks the layers into a three-dimensional network. All H atoms connected to N or O atoms find acceptors in suitable geometries. In the resulting crystal, polar and hydrogen-bond-dominated slabs alternate with stacks of organic arene rings. Although the new dihydrate shows efficient space filling, with a packing coefficient of 75.7%, it is unstable and undergoes fast desolvation at room temperature. In this process, the orthorhombic ansolvate forms as a pure phase.
Sulfanilic Acid: behavioral change related to azo food dyes in developing rats
Neurobehav Toxicol Teratol 1982 Jan-Feb;4(1):43-9.PMID:6803178doi
The effects of Sulfanilic Acid, a major azo food dye metabolite, were studied in normal developing rat pups and pups treated with 6-hydroxydopamine (60HDA). Chronic daily intraperitoneal injection of Sulfanilic Acid during the first postnatal month elicited hyperactivity and impaired shock escape performance in vehicle pups. No differences were noted in 60HDA treated rat pups receiving Sulfanilic Acid. These findings, which are similar to the results of our study of chronic administration of a food dye mix, suggest that Sulfanilic Acid may be one of the causative agents in food dye-induced behavioral changes in developing rats. While our work suggests a significant effect of azo food dyes on the developing rat central nervous system, species differences in parameters such as absorption, metabolism, and blood-brain barrier properties do not permit any extrapolation of these observations to proposed effects in children.
Sulfanilic acid-modified chitosan mini-spheres and their application for lysozyme purification from egg white
Biotechnol Prog 2018 Mar;34(2):387-396.PMID:29193855DOI:10.1002/btpr.2588.
A cation exchange matrix with zwitterionic and multimodal properties was synthesized by a simple reaction sequence coupling Sulfanilic Acid to a chitosan based support. The novel chromatographic matrix was physico-chemically characterized by ss-NMR and ζ potential, and its chromatographic performance was evaluated for lysozyme purification from diluted egg white. The maximum adsorption capacity, calculated according to Langmuir adsorption isotherm, was 50.07 ± 1.47 mg g-1 while the dissociation constant was 0.074 ± 0.012 mg mL-1 . The process for lysozyme purification from egg white was optimized, with 81.9% yield and a purity degree of 86.5%, according to RP-HPLC analysis. This work shows novel possible applications of chitosan based materials. The simple synthesis reactions combined with the simple mode of use of the chitosan matrix represents a novel method to purify proteins from raw starting materials. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:387-396, 2018.
Intestinal transport of Sulfanilic Acid in rats immunized with protein-sulfanilic acid conjugate
Pharm Res 1990 Jul;7(7):767-71.PMID:2118635DOI:10.1023/a:1015832009217.
Intestinal transport of Sulfanilic Acid was examined by means of an in vitro everted sac technique in rats immunized with a bovine gamma-globulin-sulfanilic acid conjugate. At a low concentration of Sulfanilic Acid, the intestinal transport of Sulfanilic Acid was decreased in rats immunized with bovine gamma-globulin-sulfanilic acid conjugate. This phenomenon was dose dependent and antigen specific, since there was no difference in the transport of Sulfanilic Acid at a high concentration and of an unrelated hapten. These results suggested that parenteral immunization impaired not only the intestinal transport of macromolecular antigens, as previously shown, but also the transport of the low molecular weight hapten, Sulfanilic Acid.