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Sulfosuccinimidyl oleate sodium

(Synonyms: SSO) 目录号 : GC34817

An irreversible inhibitor of CD36

Sulfosuccinimidyl oleate sodium Chemical Structure

Cas No.:1212012-37-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥792.00
现货
5mg
¥720.00
现货
10mg
¥1,125.00
现货
25mg
¥2,160.00
现货
50mg
¥3,456.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Description

Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 ?M to adipocytes.1,2 It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion.3 SSO impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.4

1.Harmon, C.M., Luce, P., Beth, A.H., et al.Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: Inhibition of fatty acid transportJ. Membr. Biol.121(3)261-268(1991) 2.Abumrad, N.A., el-Maghrabi, M.R., Amri, E.Z., et al.Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36J. Biol. Chem.268(24)17665-17668(1993) 3.Noushmehr, H., D'Amico, E., Farilla, L., et al.Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic β-cells and mediates fatty acid effects on insulin secretionDiabetes54(2)472-481(2005) 4.Nicholls, H.T., Kowalski, G., Kennedy, D.J., et al.Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissueDiabetes60(4)1100-1110(2011)

化学性质

Cas No. 1212012-37-7 SDF
别名 SSO
Canonical SMILES O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O[Na])=O
分子式 C22H36NNaO7S 分子量 481.58
溶解度 25 mg/ml in DMF; 25 mg/ml DMSO 储存条件 -20°C, sealed storage, away from moisture
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0765 mL 10.3825 mL 20.765 mL
5 mM 0.4153 mL 2.0765 mL 4.153 mL
10 mM 0.2076 mL 1.0382 mL 2.0765 mL
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