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SUN 1334H Sale

目录号 : GC31800

SUN1334H是一种有效的,可口服的,选择性的H1receptor拮抗剂,Ki值为9.7nM。

SUN 1334H Chemical Structure

Cas No.:607736-84-5

规格 价格 库存 购买数量
1mg
¥893.00
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5mg
¥1,785.00
现货
10mg
¥3,035.00
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20mg
¥5,355.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.7 nM.

SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K+-currents at concentrations as high as 100 μM[1]. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations[2].

SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs[1]. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2].

[1]. Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. [2]. Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151(1):56-69.

化学性质

Cas No. 607736-84-5 SDF
Canonical SMILES O=C(O)COC/C=C/CN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1.[H]Cl.[H]Cl
分子式 C23H28Cl2F2N2O3 分子量 489.38
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.0434 mL 10.217 mL 20.434 mL
5 mM 0.4087 mL 2.0434 mL 4.0868 mL
10 mM 0.2043 mL 1.0217 mL 2.0434 mL
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