Syringaldehyde
(Synonyms: 丁香醛) 目录号 : GC31440
A polyphenol with diverse biological activities
Cas No.:134-96-3
Sample solution is provided at 25 µL, 10mM.
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Syringaldehyde is a polyphenol that has been found in E. granulatus and has diverse biological activities.1,2,3,4 It inhibits LPS-induced COX-2 activity in RAW 264.7 cells with an IC50 value of 19.23 ?M.1 Syringaldehyde inhibits the proliferation of HCT116, Caco-2, and HT-29 colon cancer cells (IC50s = 56.3, 35.9, and 68.6 ?M, respectively).2 It decreases plasma glucose levels in a rat model of diabetes induced by streptozotocin when administered at doses ranging from 1.8 to 7.2 mg/kg.3 Syringaldehyde (25 and 50 mg/kg) reduces infarct size in a rat model of myocardial infarction induced by isoproterenol .4
1.Stanikunaite, R., Khan, S.I., Trappe, J.-M., et al.Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatusPhytother. Res.23(4)575-578(2009) 2.González-Sarrías, A., Li, L., and Seeram, N.P.Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cellsJ. Funct. Foods4(1)185-196(2012) 3.Huang, C.-H., Chen, M.-F., Chung, H.-H., et al.Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic ratsJ. Nat. Prod.75(8)1465-1468(2012) 4.Shahzad, S., Mateen, S., Mariyath, P.M.M., et al.Protective effect of syringaldehyde on biomolecular oxidation, inflammation and histopathological alterations in isoproterenol induced cardiotoxicity in ratsBiomed. Pharmacother.108625-633(2018)
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Animal experiment: |
Rats[1]Adult male albino wistar rats (weighing 180-220 g)12.5 mg/kg, 25 mg/kg, and 50 mg/kg; p.o.; for 21 daysAdult male albino wistar rats are randomly divided into six groups (n=6), first group serves as control and receives vehicle (orally) for 21 days. Second group is given Syringaldehyde in saline orally at 50 mg/kg for 21 days. Third group receives vehicle for a period of 21 days and then ISO (100 mg/kg, s.c.) on 20th and 21 st day at an interval of 24 h. Fourth group is given Syringaldehyde for 21 days at 12.5 mg/kg, p.o. and ISO on 20th and 21 st day. Fifth group receives Syringaldehyde at concentration of 25 mg/kg, p.o. for 21 days and ISO on 20th and 21 st day. The sixth group is treated with 50 mg/kg of Syringaldehyde for 21 days and ISO on 20th and 21 st day. During the experimental procedure body weight of animals are monitored and on 22nd day, 24 h after second injection of ISO, rats sre sacrificed by cervical decapitation.Note: Body weight of animals belonging to different groups did not differed significantly but heart weight of ISO challenged animals were highly elevated (p ≤ 0.05) than control rats. However, treatment of rats with Syringaldehyde significantly reduced heart weight in dose dependent way. The rats treated with Syringaldehyde alone displayed an insignificant difference from control group. |
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References: [1]. Shahzad S, et al. Protective effect of syringaldehyde on biomolecular oxidation, inflammation and histopathological alterations in isoproterenol induced cardiotoxicity in rats. Biomed Pharmacother. 2018 Dec;108:625-633. |
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| Cas No. | 134-96-3 | SDF | |
| 别名 | 丁香醛 | ||
| Canonical SMILES | O=CC1=CC(OC)=C(O)C(OC)=C1 | ||
| 分子式 | C9H10O4 | 分子量 | 182.17 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml,Ethanol: 1 mg/ml | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL |
| 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL |
| 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet