TACI Human
目录号 : GP20932Tumor Necrosis Factor Receptor 13B Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by: | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | CD267; CVID; CVID2; TACI; TNFRSF14B; Tumor necrosis factor receptor superfamily; member 13B; Tumor necrosis factor receptor superfamily; member 13B; isoform CRA_a; TNFRSF13B. | ||
| Amino Acid Sequence | MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV | ||
| Solubility | It is recommended to reconstitute the lyophilized TACI in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized TACI although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution TACI should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). | ||
| Biological Activity | Fully biologically active when compared to standard. The biological activity is determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/mlcorresponding to a specific activity of 334-1000 IU/mg. | ||
| Formulation | TACI protein was lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4. | ||
TNFRSF13B (TACI) is a transmembrane receptor protein found predominantly on the surface of B cells (a significant part of the immune system). TACI was at first discovered owing to its ability to interact with calcium-modulator and cyclophilin ligand (CAML). Later on, it was found that TACI plays a key role in humoral immunity by interacting with two members of the TNF family. Also, TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.
Fully biologically active when compared to standard. The biological activity is determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/mlcorresponding to a specific activity of 334-1000 IU/mg.
Lyophilized TACI although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution TACI should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).