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TAN 420E Sale

(Synonyms: Dihydroherbimycin A) 目录号 : GC44989

A bacterial metabolite

TAN 420E Chemical Structure

Cas No.:91700-93-5

规格 价格 库存 购买数量
500μg
¥3,066.00
现货
2.5mg
¥13,808.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 1.3 μM) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 μg/ml. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml). It is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 μg/ml, respectively).

Chemical Properties

Cas No. 91700-93-5 SDF
别名 Dihydroherbimycin A
Canonical SMILES OC1=CC(N2)=C(O)C([C@@](OC)([H])[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)=C1
分子式 C30H44N2O9 分子量 576.7
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.734 mL 8.67 mL 17.34 mL
5 mM 0.3468 mL 1.734 mL 3.468 mL
10 mM 0.1734 mL 0.867 mL 1.734 mL
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Research Update

Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15

J Nat Prod 2013 Sep 27;76(9):1619-26.PMID:23947794DOI:PMC3852429

Bacterial strains belonging to the class actinomycetes were isolated from the soil near a thermal vent of the Ruth Mullins coal fire (Appalachian Mountains of eastern Kentucky). High-resolution electrospray ionization mass spectrometry and ultraviolet absorption profiles of metabolites from one of the isolates (Streptomyces sp. RM-7-15) revealed the presence of a unique set of metabolites ultimately determined to be herbimycins D-F (1-3). In addition, herbimycin A (4), dihydroherbimycin A (TAN 420E) (7), and the structurally distinct antibiotic bicycylomycin were isolated from the crude extract of Streptomyces sp. RM-7-15. Herbimycins A and D-F (1-3) displayed comparable binding affinities to the Hsp90α. While the new analogues were found to be inactive in cancer cell cytotoxicity and antimicrobial assays, they may offer new insights in the context of nontoxic ansamycin-based Hsp90 inhibitors for the treatment of neurodegenerative disease.