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Taraxerol Sale

(Synonyms: 蒲公英萜醇) 目录号 : GC60352

Taraxerol 具有抗炎和抗癌作用。

Taraxerol Chemical Structure

Cas No.:127-22-0

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1mg
¥700.00
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5mg
¥1,750.00
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10mg
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Sample solution is provided at 25 µL, 10mM.

Description

Taraxerol has anti-inflammatory and anticancer effects. Taraxerol attenuates acute inflammation by inhibiting NF-κB signaling[5,6].

Taraxerol downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation[3].

Taraxerol enhanced ROS levels and attenuated the MMP (Δψm) in HeLa cells. Taraxerol induced apoptosis mainly via the mitochondrial pathway including the release of cytochrome c to the cytosol and activation of caspases 9 and 3, and anti-poly (ADPribose) polymerase (PARP). Taraxerol could induce the down-regulation of the anti-apoptotic protein Bcl-2 and up-regulation of pro-apoptotic protein Bax. It suppressed the PI3K/ Akt signaling pathway [1].

Taraxerol treatment significantly attenuated carrageenan induced paw edema 2 h onward. The anti-inflammatory effect of taraxerol was sustained up to 4 h[2]. Taraxerol (20mg/kg, p.o.) treatment stimulated glucose metabolism in skeletal muscle, regulated blood glycaemic status and lipid profile in the sera, reduced the secretion of pro-inflammatory cytokines, and restored the renal physiology in T2D rats[4]. AChE activity inhibition in animals and indicate that Taraxerol has anti-amnesic activity that may hold significant therapeutic value in alleviating certain memory impairments observed in AD[7].

References:
[1]: Yaoi X, Lu B, et,al. Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells. Cell J. 2017 Oct;19(3):512-519. doi: 10.22074/cellj.2017.4543. Epub 2017 Aug 19. PMID: 28836414; PMCID: PMC5572297.
[2]: Khanra R, Dewanjee S, et,al. Taraxerol, a pentacyclic triterpene from Abroma augusta leaf, attenuates acute inflammation via inhibition of NF-κB signaling. Biomed Pharmacother. 2017 Apr;88:918-923. doi: 10.1016/j.biopha.2017.01.132. Epub 2017 Feb 6. PMID: 28178622.
[3]: Yao X, Li G, et,al. Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation. Int Immunopharmacol. 2013 Feb;15(2):316-24. doi: 10.1016/j.intimp.2012.12.032. Epub 2013 Jan 15. PMID: 23333629.
[4]: Khanra R, Bhattacharjee N, et,al. Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats. Biomed Pharmacother. 2017 Oct;94:726-741. doi: 10.1016/j.biopha.2017.07.112. Epub 2017 Aug 9. PMID: 28802226.
[5]: Khanra R, Dewanjee S, et,al. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. J Transl Med. 2015 Jan 16;13:6. doi: 10.1186/s12967-014-0364-1. PMID: 25591455; PMCID: PMC4301895.
[6]: Tsao CC, Shen YC, et,al. New diterpenoids and the bioactivity of Erythrophleum fordii. Bioorg Med Chem. 2008 Nov 15;16(22):9867-70. doi: 10.1016/j.bmc.2008.09.021. Epub 2008 Sep 12. PMID: 18926710.
[7]: Berté TE, Dalmagro AP, Zimath PL, Gon?alves AE, Meyre-Silva C, Bürger C, Weber CJ, Dos Santos DA, Cechinel-Filho V, de Souza MM. Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer's disease: Effects against scopolamine and streptozotocin-induced cognitive dysfunctions. Steroids. 2018 Apr;132:5-11. doi: 10.1016/j.steroids.2018.01.002. PMID: 29355563.

Taraxerol 具有抗炎和抗癌作用。蒲公英甾醇通过抑制 NF-κB 信号通路减轻急性炎症[5,6]

紫杉醇通过干扰 TAK1 和 Akt 的激活来下调巨噬细胞中促炎介质的表达,从而阻止 NF-κB 激活[3]

紫杉醇增强了 HeLa 细胞中的 ROS 水平并减弱了 MMP (δψm)。 Taraxerol 主要通过线粒体途径诱导细胞凋亡,包括将细胞色素 c 释放到胞质溶胶和半胱天冬酶 9 和 3 的激活,以及抗多聚 (ADPribose) 聚合酶 (PARP)。 Taraxerol 可诱导抗凋亡蛋白 Bcl-2 的下调和促凋亡蛋白 Bax 的上调。抑制PI3K/Akt信号通路[1]

2 小时后,紫杉醇处理可显着减轻角叉菜胶诱导的爪水肿。蒲公英甾醇的抗炎作用可持续长达4 h[2]。蒲公英甾醇(20 毫克/千克,口服)治疗可刺激骨骼肌中的葡萄糖代谢,调节血糖状态和血清中的脂质分布,减少促炎细胞因子的分泌,并恢复 T2D 大鼠的肾脏生理机能[4] 。动物 AChE 活性抑制表明 Taraxerol 具有抗遗忘活性,在减轻 AD[7] 中观察到的某些记忆障碍方面可能具有重要的治疗价值。

实验参考方法

Cell experiment [1]:

Cell lines

RAW264.7 macrophages

Preparation Method

The cells were treated with various concentrations of taraxerol or LPS plus taraxerol for 24 h. Then cells were incubated with 5 mg/ml of MTT working solution for 4 h at 37°C. After being treated with 100 µl of DMSO to dissolve the crystals, the cells were detected under an ELx800 Universal Microplate Reader to measure the absorbance at 570 nm.

Reaction Conditions

0、10、20、40 μM Taraxerol for 1h

Applications

Taraxerol downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation.

Animal experiment [2]:

Animal models

Wistar rats (♂, 150 ± 20 g)

Preparation Method

groups were treated with taraxerol at the doses of 5 and 10 mg/kg, i.p., respectively.

Dosage form

5 and 10 mg/kg Taraxerol for 0-4h

Applications

Taraxerol treatment significantly attenuated carrageenan induced paw edema 2 h onward. The anti-inflammatory effect of taraxerol was sustained up to 4 h.

References:

[1]. Yao X, Li G, et,al. Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation. Int Immunopharmacol. 2013 Feb;15(2):316-24. doi: 10.1016/j.intimp.2012.12.032. Epub 2013 Jan 15. PMID: 23333629.
[2]. Khanra R, Dewanjee S, et,al. Taraxerol, a pentacyclic triterpene from Abroma augusta leaf, attenuates acute inflammation via inhibition of NF-κB signaling. Biomed Pharmacother. 2017 Apr;88:918-923. doi: 10.1016/j.biopha.2017.01.132. Epub 2017 Feb 6. PMID: 28178622.

化学性质

Cas No. 127-22-0 SDF
别名 蒲公英萜醇
Canonical SMILES C[C@]12C3=CC[C@@](C)(CCC(C)(C)C4)[C@]4([H])[C@@]3(CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O)CC5)C)([H])CC2)C)C
分子式 C30H50O 分子量 426.72
溶解度 ≥ 40 mg/mL in DMSO 储存条件 4°C, protect from light
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1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL
10 mM 0.2343 mL 1.1717 mL 2.3435 mL
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