TARDBP (1-414) Human, His
目录号 : GP24778TAR DNA Binding Protein (1-414 a.a.) Human Recombinant, His Tag
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90% as determined by SDS-PAGE. | Source | E.coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | ALS10;TDP43; TAR DNA-binding protein 43; TDP-43; TARDBP. | ||
| Amino Acid Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSEY IRVTEDENDE PIEIPSEDDG TVLLSTVTAQ FPGACGLRYR NPVSQCMRGV RLVEGILHAP DAGWGNLVYV VNYPKDNKRK MDETDASSAV KVKRAVQKTS DLIVLGLPWK TTEQDLKEYF STFGEVLMVQ VKKDLKTGHS KGFGFVRFTE YETQVKVMSQ RHMIDGRWCD CKLPNSKQSQ DEPLRSRKVF VGRCTEDMTE DELREFFSQY GDVMDVFIPK PFRAFAFVTF ADDQIAQSLC GEDLIIKGIS VHISNAEPKH NSNRQLERSG RFGGNPGGFG NQGGFGNSRG GGAGLGNNQG SNMGGGMNFG AFSINPAMMA AAQAALQSSW GMMGMLASQQ NQSGPSGNNQ NQGNMQREPN QAFGSGNNSY SGSNSGAAIG WGSASNAGSG SGFNGGFGSS MDSKSSGWGM. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | TARDBPprotein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glyceroland 0.4M urea. | ||
TARDNA Binding Protein (TARDBP) was initially recognized as a transcriptional repressorwhich binds to chromosomally integrated TAR DNA and represses HIV-1transcription. In addition, TARDBP has been detected in individuals diagnosedwith chronic traumatic encephalopathy as well, which is a condition that oftenimitates ALS and hasbeen related with athletes who have experienced multiple concussions and othertypes of head injury.TARDBPhas been shown to bind both DNA and RNA, it has multiple functions intranscriptional repression, pre-mRNA splicing and translational regulation.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.