Taurine-d4

Taurine-d₄ is intended for use as an internal standard for the quantification of taurine by GC- or LC-MS. Taurine is a sulfur-containing amino acid produced endogenously and also ingested in the diet.¹ It is ubiquitously present in most cells and has diverse biological activities, including antioxidative, anticancer, cardioprotective, and neuroprotective properties.^1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals when used at concentrations ranging from 125 to 1,000 µg/ml and decreases the viability of MCF-7 and MDA-MB-231 human breast cancer cells.² It prevents left ventricular dysfunction in the mdx mouse model of late-stage Duchenne muscular dystrophy when administered at a dose of 1 g/kg per day for six months.³ Taurine (100 µM) prevents neurotoxicity induced by amyloid-β (Aβ) or the glutamate receptor agonists glutamate, NMDA , or kainic acid in chick embryonic retinal neurons, an effect that can be blocked by the GABA_A receptor antagonist picrotoxin .⁴

1.Schaffer, S., and Kim, H.W.Effects and mechanisms of taurine as a therapeutic agentBiomol. Ther. (Seoul)26(3)225-241(2018) 2.Choi, E.-J., Tang, Y., Lee, C.B., et al.Investigation of antioxidant and anticancer potential of taurine by means of multiple chemical and biological assaysTaurine 9(2018) 3.Mele, A., Manturano, P., De Bellis, M., et al.A long-term treatment with taurine prevents cardiac dysfunction in mdx miceTransl. Res.20482-99(2019) 4.Louzada, P.R., Lima, A.C.P., MendonÇa-Silva, D.L., et al.Taurine prevents the neurotoxicity of ß-amyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer’s disease and other neurological disordersFASEB J.18(3)511-518(2004)