Taurochenodeoxycholic acid (12-Deoxycholyltaurine)

Taurochenodeoxycholic acid (TCDCA) is a taurine-conjugated form of the primary bile acid chenodeoxycholic acid .¹ Serum levels of TCDCA increase approximately 5-fold within two hours and begin to decrease within four hours during an oral lipid tolerance test in humans.² Serum levels of TCDCA are increased in patients with liver cirrhosis and may serve as a marker of disease progression.³

TCDCA MaxSpec  standard is a quantitative grade standard of TCDCA that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This TCDCA MaxSpec  standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

牛磺酸基合成的原胆酸对羟基基团的一种共轭物质，称为牛磺酸基合成的降解胆酸，它是主要的胆汁酸之一。¹ 在口服脂质耐受性试验中，人体血清中的TCDCA水平在两小时内增加了约5倍，并在四小时内开始下降。² 肝硬化患者的血清TCDCA水平增加，可能作为疾病进展的标志物。³

TCDCA MaxSpec标准是一种定量级别的TCDCA标准，专门为质谱和相关应用而制备，需要量化重现性。该溶液经过重量法制备，密封在惰性气体氩气下的失活玻璃安瓿中提供。通过与独立制备的校准标准进行比较，已验证浓度。验证的浓度提供在分析证书上。该TCDCA MaxSpec标准保证符合标识、纯度、稳定性和浓度规范，并提供具有批次特异性的分析证书。持续进行稳定性测试以确保在产品的货架寿命期间浓度保持准确。注意：加入到小瓶中的溶液量超过了所列数量。因此，需要准确测量体积以准备校准标准。遵循推荐的存储和处理条件以维护产品质量。

1.Hoffman, A.F.The continuing importance of bile acids in liver and intestinal diseaseArch. Intern. Med.159(22)2647-2658(1999) 2.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 3.Wang, X., Xie, G., Zhao, A., et al.Serum bile acids are associated with pathological progression of hepatitis B-induced cirrhosisJ. Proteome Res.15(4)1126-1134(2016)