Terbuthylazine
(Synonyms: 特丁津) 目录号 : GC30065
A triazine herbicide
Cas No.:5915-41-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Terbuthylazine is a triazine herbicide.1 Terbuthylazine is active against a variety of broadleaf and grass weeds, including A. retroflexus, D. stramonium, S. nigrum, and S. halepense, when used in combination with (S)-metolachlor.2 It has been found in surface groundwater and soil samples.3,4 Formulations containing terbuthylazine have been used for weed control in agriculture and as algicides in water coolant systems.
1.?těpánová, S., Plhalová, L., Dole?elová, P., et al.The effects of subchronic exposure to terbuthylazine on early developmental stages of common carpSci. World J.615920(2012) 2.Meseld?ija, M., and Dudi?, M.Terbuthylazine application with herbicides of different mode of action in maize cropIX International Scientific Agriculture Symposium(2018) 3.Guzzella, L., Pozzoni, F., and Giuliano, G.Herbicide contamination of surficial groundwater in Northern ItalyEnviron. Pollut.142(2)344-353(2006) 4.Sahid, I.B., and Teoh, S.S.Persistence of terbuthylazine in soilsBull. Environ. Contam. Toxicol.52(2)226-230(1994)
| Cas No. | 5915-41-3 | SDF | |
| 别名 | 特丁津 | ||
| Canonical SMILES | CCNC1=NC(Cl)=NC(NC(C)(C)C)=N1 | ||
| 分子式 | C9H16ClN5 | 分子量 | 229.71 |
| 溶解度 | DMSO : 23 mg/mL (100.13 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.3533 mL | 21.7666 mL | 43.5332 mL |
| 5 mM | 0.8707 mL | 4.3533 mL | 8.7066 mL |
| 10 mM | 0.4353 mL | 2.1767 mL | 4.3533 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Terbuthylazine and desethylterbuthylazine: Recent occurrence, mobility and removal techniques
Chemosphere 2018 Jul;202:94-104.29554512 10.1016/j.chemosphere.2018.03.091
The herbicide Terbuthylazine (TBA) has displaced atrazine in most of EU countries, becoming one of the most regularly used pesticides and, therefore, frequently detected in natural waters. The affinity of TBA for soil organic matter suggests prolonged contamination; degradation leads to the release of the metabolite desethylterbuthylazine (DET), which has higher water solubility and binds more weakly to organic matter compared to the parent compound, resulting in higher associated risk for contamination of groundwater resources. Additionally, TBA and DET are chemicals of emerging concern because of their persistence and toxicity towards aquatic organisms; moreover, they are known to have significant endocrine disruption capacity to wildlife and humans. Conventional treatments applied during drinking water production do not lead to the complete removal of these chemicals; activated carbon provides the greatest efficiency, whereas ozonation can generate by-products with comparable oestrogenic activity to atrazine. Hydrogen peroxide alone is ineffective to degrade TBA, while UV/H2O2 advanced oxidation and photocatalysis are the most effective processes for oxidation of TBA. It has been determined that direct photolysis gives the highest degradation efficiency of all UV/H2O2 treatments, while most of the photocatalytic degradation is attributed to OH radicals, and TiO2 solar-photocatalytic ozonation can lead to almost complete TBA removal in ∿0 min. Constructed wetlands provide a valuable buffer capacity, protecting downstream surface waters from contaminated runoff. TBA and DET occurrence are summarized and removal techniques are critically evaluated and compared, to provide the reader with a comprehensive guide to state-of-the-art TBA removal and potential future treatments.
Terbuthylazine herbicide: an alternative to atrazine for weed control in glyphosate-tolerant maize
J Environ Sci Health B 2022;57(8):609-616.35758289 10.1080/03601234.2022.2088015
It is proposed that the herbicide Terbuthylazine is more effective than atrazine in controlling weeds in maize. This study aimed to evaluate the efficacy of Terbuthylazine and atrazine in a mixture with glyphosate in glyphosate-tolerant maize for post-emergence application. The experiment was conducted over three trials using randomized blocks with 4 repetitions and 10 treatments, composed by Terbuthylazine rates + glyphosate, atrazine rates + glyphosate, [atrazine + mesotrione] + glyphosate, atrazine + tembotrione, isolated glyphosate, and nontreated control. Trial 1 were infested with Bidens subalternans DC. and Commelina benghalensis L; trial 2 with Urochloa plantaginea (Link) R. D. Webster, Ipomoea spp., volunteer soybean, B. subalternans, and grasses; and trial 3 infestation with C. benghalensis, U. plantaginea, Ipomoea spp., volunteer soybean, B. subalternans, Amaranthus hybridus L., and grasses. Weed control, crop injury, and yield were evaluated. Terbuthylazine + glyphosate showed an efficacy equivalent to that of atrazine or [atrazine + mesotrione] + glyphosate in the control of broadleaves and C. benghalensis. In contrast, the efficacy of Terbuthylazine was similar or greater than that observed for atrazine in controlling grasses, depending on the location. Terbuthylazine is an important partner of glyphosate in controlling weeds in maize and is an alternative to atrazine.
Bioaccumulation and toxicity of Terbuthylazine in earthworms (Eisenia fetida)
Environ Toxicol Pharmacol 2023 Jan;97:104016.36435387 10.1016/j.etap.2022.104016
Terbuthylazine is an effective and widely used s-triazine herbicide. However, limited data exists on its toxicity and bioaccumulation in earthworms (Eisenia fetida). In this study, we investigated the bioaccumulation, antioxidant enzyme activity, detoxification enzyme activity, and DNA damage in earthworms when exposed to Terbuthylazine. The results indicated that Terbuthylazine in soil had low bioaccumulation in earthworms and the biota-soil accumulation factors of Terbuthylazine declined with an increasing soil Terbuthylazine concentration. In the enzyme activity assays, the superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST) activities showed upward trends when compared with the control. The carboxylesterase (CarE) activity increased on day 21. The 8-hydroxy-2-deoxyguanosine (8-OHdG) content, a DNA damage bioindicator, was higher than that of the control on day 21. Combined with the integrated biological response index version 2 analysis, these results can provide a comprehensive evaluation of the toxicological effects that Terbuthylazine has on earthworms and soil ecosystems.
Updated peer review of the pesticide risk assessment for the active substance Terbuthylazine in light of confirmatory data submitted
EFSA J 2019 Sep 19;17(9):e05817.32626435 PMC7009257
The conclusions of EFSA following the peer review of the initial risk assessment carried out by the competent authority of the rapporteur Member State, the United Kingdom, for the pesticide active substance Terbuthylazine are reported. The context of the peer review was that requested by the European Commission following the submission and evaluation of confirmatory data on groundwater metabolites. The conclusions were reached on the basis of the evaluation of the representative uses of Terbuthylazine as a herbicide on maize and sorghum and taking into account the scientific opinion of the EFSA Panel on Plant Protection Products and their Residues (PPR) on the setting of health-based reference values for metabolites of the active substance Terbuthylazine. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Concerns are identified.
Peer review of the pesticide risk assessment for the active substance Terbuthylazine in light of confirmatory data submitted
EFSA J 2017 Jun 29;15(6):e04868.32625529 PMC7010187
The conclusions of EFSA following the peer review of the initial risk assessment carried out by the competent authority of the rapporteur Member State, the United Kingdom, for the pesticide active substance Terbuthylazine are reported. The context of the peer review was that requested by the European Commission following the submission and evaluation of confirmatory data on groundwater metabolites. The conclusions were reached on the basis of the evaluation of the representative uses of Terbuthylazine as a herbicide on maize and sorghum. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Concerns are identified.