Terphenyllin
(Synonyms: 三联苯曲菌素) 目录号 : GC34835
A fungal metabolite with antibacterial properties
Cas No.:52452-60-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Terphenyllin is a flavonoid metabolite originally isolated from A. candidus that has antibacterial and cytotoxic properties.1,2 It is active against methicillin-resistant S. aureus 1 (MRSA-1), MRSA-2, and V. vulnificus (MICs = 31.27-31.47 ?g/ml) and cytotoxic to HeLa, A549, and HepG2 cells (IC50s = 18.87, 12.33, and 21.2 ?M, respectively).2 Terphenyllin inhibits HIV-1 integrase in coupled and strand transfer assays with IC50 values of 17.7 ?M and 47.7 ?M.3
1.Marchelli, R., and Vining, L.C.Terphenyllin, a novel p-terphenyl metabolite from aspergillus candidusJ. Antibiot. (Tokyo)28(4)328-331(1975) 2.Wang, W., Liao, Y., Tang, C., et al.Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1Mar. Drugs15(11)E348(2017) 3.Singh, S.B., Jayasuriya, H., Dewey, R., et al.Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolitesJ. Ind. Microbiol. Biotechnol.30(12)721-731(2003)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.9555 mL | 14.7776 mL | 29.5552 mL |
| 5 mM | 0.5911 mL | 2.9555 mL | 5.911 mL |
| 10 mM | 0.2956 mL | 1.4778 mL | 2.9555 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。