(-)-α-Terpineol
(Synonyms: (-)-α-松油醇; (S)-α-Terpineol) 目录号 : GC40670
(-)-α-Terpineol ((S)-α-Terpineol) 是一种单萜化合物，是Melaleuca alternifolia中化合物之一。(-)-α-Terpineol 具有抗氧化和抗炎活性。
Cas No.:10482-56-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(-)-α-Terpineol ((S)-α-Terpineol), a monoterpene compound, is one of compounds in Melaleuca alternifolia. (-)-α-Terpineol has antioxidant and anti-inflammatory activities.
(-)-α-Terpineol ((S)-α-Terpineol) 是一种单萜化合物，是Melaleuca alternifolia中化合物之一。(-)-α-Terpineol 具有抗氧化和抗炎活性。
| Cas No. | 10482-56-1 | SDF | |
| 别名 | (-)-α-松油醇; (S)-α-Terpineol | ||
| Canonical SMILES | OC(C)(C)[C@@H]1CC=C(C)CC1 | ||
| 分子式 | C10H18O | 分子量 | 154.25 |
| 溶解度 | DMSO : 100 mg/mL (648.30 mM; Need ultrasonic) | 储存条件 | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.483 mL | 32.4149 mL | 64.8298 mL |
| 5 mM | 1.2966 mL | 6.483 mL | 12.966 mL |
| 10 mM | 0.6483 mL | 3.2415 mL | 6.483 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Synthesis of Terpineol from Alpha-Pinene Catalyzed by α-Hydroxy Acids
Molecules 2022 Feb 8;27(3):1126.PMID:35164391DOI:10.3390/molecules27031126.
We report the use of five alpha-hydroxy acids (citric, tartaric, mandelic, lactic and glycolic acids) as catalysts in the synthesis of Terpineol from alpha-pinene. The study found that the hydration rate of pinene was slow when only catalyzed by alpha-hydroxyl acids. Ternary composite catalysts, composed of AHAs, phosphoric acid, and acetic acid, had a good catalytic performance. The reaction step was hydrolysis of the intermediate terpinyl acetate, which yielded Terpineol. The optimal reaction conditions were as follows: alpha-pinene, acetic acid, water, citric acid, and phosphoric acid, at a mass ratio of 1:2.5:1:(0.1-0.05):0.05, a reaction temperature of 70 °C, and a reaction time of 12-15 h. The conversion of alpha-pinene was 96%, the content of alpha-terpineol was 46.9%, and the selectivity of alpha-terpineol was 48.1%. In addition, the catalytic performance of monolayer graphene oxide and its composite catalyst with citric acid was studied, with acetic acid used as an additive.
Fragrance material review on Terpineol
Food Chem Toxicol 2008 Nov;46 Suppl 11:S275-9.PMID:18640175DOI:10.1016/j.fct.2008.06.075.
A toxicologic and dermatologic review of Terpineol when used as a fragrance ingredient is presented.
A method to control Terpineol production from turpentine by acid catalysts mixing
Heliyon 2020 Oct 8;6(10):e04984.PMID:33083585DOI:10.1016/j.heliyon.2020.e04984.
Terpineol, a promising valorisation product of pine industry, is widely used as an active ingredient for disinfectant soap, cleansers, perfumes, and pharmaceutical purposes. Synthesis of Terpineol is generally carried out by separation of α-pinene compounds from crude turpentine through fractionation and then hydrated (addition of water) with the help of acid catalysts. However, direct turpentine hydration without pre-fractionation process can be more beneficial from economic and process point of views. This study aims to investigate the effect of both single and mixed/combined catalysts towards Terpineol yield. Combined strong and weak acid catalysts were required to obtain high feed conversion and Terpineol yield. The selectivity of Terpineol is then correlated to the solubility of a weak/organic acid. In this study, the highest yield of Terpineol was 54.0 ± 8.2%-w/w using combination of formic acid and sulphuric acid.
Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor
Biomolecules 2020 May 20;10(5):792.PMID:32443870DOI:10.3390/biom10050792.
Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress and genetic factors acting through immunological and endocrine responses generate structural and functional changes in the brain, inducing neurogenesis and neurotransmission dysfunction. Terpineol, monoterpenoid alcohol, has shown immunomodulatory and neuroprotective effects, but there is no report about its antidepressant potential. Herein, we used a single lipopolysaccharide (LPS) injection to induce a depressive-like effect in the tail suspension test (TST) and the splash test (ST) for a preventive and therapeutic experimental schedule. Furthermore, we investigated the antidepressant-like mechanism of action of Terpineol while using molecular and pharmacological approaches. Terpineol showed a coherent predicted binding mode mainly against CB1 and CB2 receptors and also against the D2 receptor during docking modeling analyses. The acute administration of Terpineol produced the antidepressant-like effect, since it significantly reduced the immobility time in TST (100-200 mg/kg, p.o.) as compared to the control group. Moreover, Terpineol showed an antidepressant-like effect in the preventive treatment that was blocked by a nonselective dopaminergic receptor antagonist (haloperidol), a selective dopamine D2 receptor antagonist (sulpiride), a selective CB1 cannabinoid receptor antagonist/inverse agonist (AM281), and a potent and selective CB2 cannabinoid receptor inverse agonist (AM630), but it was not blocked by a nonselective adenosine receptor antagonist (caffeine) or a β-adrenoceptor antagonist (propranolol). In summary, molecular docking suggests that CB1 and CB2 receptors are the most promising targets of Terpineol action. Our data showed Terpineol antidepressant-like modulation by CB1 and CB2 cannabinoid receptors and D2-dopaminergic receptors to further corroborate our molecular evidence.