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tetranor-PGDM-d6 Sale

(Synonyms: tetranorProstaglandin D Metabolited6) 目录号 : GC48156

An internal standard for the quantification of tetranor-PGDM

tetranor-PGDM-d6 Chemical Structure

Cas No.:1314905-92-4

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25 μg
¥3,751.00
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50 μg
¥7,127.00
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100 μg
¥13,500.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

tetranor-PGDM-d6 contains six deuterium atoms at the 17, 17', 18, 18', 19 and 19' positions. It is intended for use as an internal standard for the quantification of tetranor-PGDM by GC- or LC-mass spectrometry (MS). Prostaglandin D2 (PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.1 PGD2 is also produced in the brain by lipocalin PGD-synthase also known as β-trace.2,3 In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.4 tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and murine urine.5 The levels of tetranor-PGDM and 2,3-dinor-11b-PGF, a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in mouse urine at a level of 8.1 ± 1.3 ng/mg creatinine.5

1.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 2.Hayaishi, O.Sleep-wake regulation by prostaglandins D2 and E2J. Biol. Chem.263(29)14593-14596(1988) 3.Onoe, H., Ueno, R., Fujita, I., et al.Prostaglandin D2, a cerebral sleep-inducing substance in monkeysProc. Natl. Acad. Sci. U.S.A.85(11)4082-4086(1988) 4.Giles, H., and Leff, P.The biology and pharmacology of PGD2Prostaglandins35(2)277-300(1988) 5.Song, W.L., Wang, M., Ricciotti, E., et al.Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humansJ. Biol. Chem.283(2)1179-1188(2008)

Chemical Properties

Cas No. 1314905-92-4 SDF
别名 tetranorProstaglandin D Metabolited6
Canonical SMILES O[C@@H](C1)[C@H](CCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)C1=O
分子式 C16H18O7D6 分子量 334.4
溶解度 DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: Not stable,PBS (pH 7.2): 1 mg/ml 储存条件 Store at -80°C
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1 mg 5 mg 10 mg
1 mM 2.9904 mL 14.9522 mL 29.9043 mL
5 mM 0.5981 mL 2.9904 mL 5.9809 mL
10 mM 0.299 mL 1.4952 mL 2.9904 mL
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