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Thiarabine (OSI-7836) Sale

(Synonyms: OSI-7836) 目录号 : GC31868

Thiarabine (OSI-7836) (OSI-7836) 显示出有效的抗肿瘤活性和对 DNA 合成的抑制作用。

Thiarabine (OSI-7836) Chemical Structure

Cas No.:26599-17-7

规格 价格 库存 购买数量
250mg 待询 待询
500mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

Description

Thiarabine (OSI-7836) shows potent anti-tumor activity and inhibition of DNA synthesis.

Thiarabine has demonstrated exceptional antitumor activity against numerous human tumor xenografts in mice, being superior to gemcitabine, clofarabine, or cytarabine. Unlike cytarabine, Thiarabine demonstrates excellent activity against solid tumor xenografts, suggesting that this agent has the kind of robust activity in animal models that leads to clinical utility. Thiarabine is effective orally (bioavailability of approximately 16%) and with once per day dosing: Two characteristics that distinguish it from cytarabine. Although both the structure and basic mechanism of action of Thiarabine are similar to that of cytarabine, there are many quantitative differences in the biochemical pharmacology of these two agents that can explain the superior antitumor activity of Thiarabine. Two important attributes are the long retention time of the 5'-triphosphate of thiarabine in tumor cells and its potent inhibition of DNA synthesis. The biochemical pharmacology of Thiarabine is also different from that of gemcitabine[1].

[1]. Parker WB, et al. Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity. Curr Med Chem. 2015;22(34):3881-96.

化学性质

Cas No. 26599-17-7 SDF
别名 OSI-7836
Canonical SMILES O[C@H]1[C@H](O)[C@@H](CO)S[C@H]1N2C=CC(N)=NC2=O
分子式 C9H13N3O4S 分子量 259.28
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.8568 mL 19.2842 mL 38.5683 mL
5 mM 0.7714 mL 3.8568 mL 7.7137 mL
10 mM 0.3857 mL 1.9284 mL 3.8568 mL
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