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Thielavin A Sale

目录号 : GC45033

A natural COX and glucose-6-phosphatase inhibitor

Thielavin A Chemical Structure

Cas No.:71950-66-8

规格 价格 库存 购买数量
500μg
¥4,951.00
现货
2.5mg
¥19,804.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 and the conversion of PGH2 to PGE2 . Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 µM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 µM; Ki = 27.8 µM).

Chemical Properties

Cas No. 71950-66-8 SDF
Canonical SMILES CC1=C(O)C=C(C)C(C(OC2=C(C)C(C)=C(C(OC3=C(C)C(C)=C(C(O)=O)C(O)=C3C)=O)C(O)=C2C)=O)=C1O
分子式 C29H30O10 分子量 538.5
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.857 mL 9.2851 mL 18.5701 mL
5 mM 0.3714 mL 1.857 mL 3.714 mL
10 mM 0.1857 mL 0.9285 mL 1.857 mL
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Research Update

Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola

J Antibiot (Tokyo) 1981 Dec;34(12):1562-8.PMID:7333968DOI:10.7164/antibiotics.34.1562.

Two potent inhibitors of prostaglandin biosynthesis, Thielavin A (C31H34O10) and B (C29H30O10), were isolated from cultures of Thielavia terricola. Both of these compounds were shown to be structurally related to depsides, thus consisting of three hydroxybenzoic acid groups. Concentrations required for 50% inhibition of the conversion of 14C-arachidonic acid into prostaglandins F2 alpha plus E2 by microsomes of ram seminal vesicles were 12 microM for Thielavin A and 9 microM for thielavin B, respectively. Of the enzymatic steps involved in prostaglandin synthesis, Thielavin A specifically inhibited the conversion of arachidonic acid into prostaglandin H2, while prostaglandin E2 synthesis from the endoperoxide was the most sensitive to thielavin B. Thromboxane A2 synthesis from prostaglandin H2 in bovine platelet microsomes were inhibited by 50% at concentrations of 150 and 350 microM of Thielavin A and B, respectively. Thielavin B was significantly effective on carrageenan-induced oedema of rats when administered intravenously but on on oral administration. The anti-inflammatory activity was not detectable with Thielavin A either on intravenous injection or on oral administration.