Tilmicosin-d3
(Synonyms: LY-177370-d3; EL-870-d3) 目录号 : GC49076
An internal standard for the quantification of tilmicosin
Cas No.:2714486-61-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Tilmicosin-d3 is intended for use as an internal standard for the quantification of tilmicosin by GC- or LC-MS. Tilmicosin is a macrolide antibiotic.1 It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM), and inhibits bacterial protein synthesis (IC50 = 0.36 µM). Tilmicosin (75 mg/kg) increases serum creatine kinase (CK), the MB isoform of CK (CK-MB), and malondialdehyde (MDA) levels in mice, indicating cardiotoxicity.2 Formulations containing tilmicosin have been used in the treatment of respiratory diseases in sheep and cattle.
1.Andersen, N.M., Poehlsgaard, J., Warrass, R., et al.Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolidesAntimicrob. Agents Chemother.56(11)6033-6036(2012) 2.Kart, A., Yapar, K., Karapehlivan, M., et al.The possible protective effect of ?-carnitine on tilmicosin-induced cardiotoxicity in miceJ. Vet. Med. A Physiol. Pathol. Clin. Med.54(3)144-146(2007)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1465 mL | 5.7326 mL | 11.4653 mL |
| 5 mM | 0.2293 mL | 1.1465 mL | 2.2931 mL |
| 10 mM | 0.1147 mL | 0.5733 mL | 1.1465 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。