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Timolol Maleate Sale

(Synonyms: (S)-马来酸噻吗洛尔; L-714,465 Maleate; MK 950) 目录号 : GC12468

A non-selective β-adrenergic receptor antagonist

Timolol Maleate Chemical Structure

Cas No.:26921-17-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥378.00
现货
100mg
¥389.00
现货
250mg
¥798.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

(S)-Timolol Maleate (L-714,465 Maleate;MK 950), is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).

(S)-Timolol Maleate (L-714,465 Maleate;MK 950), 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals.

References:
[1]. Deepika Aggarwal, Indu P. Kaur. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. International Journal of Pharmaceutics. 2005, 290(1-2): 155-159.
[2]. Mandagere AK, Thompson TN, Hwang KK. Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates. J Med Chem. 2002;45(2):304-11.
[3]. A.H El-Kamel. In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate. International Journal of Pharmaceutics. 2002, 241, (1) :47-55.
[4]. Konstas AG, Maltezos AC, Gandi S, et al. Comparison of 24-hour intraocular pressure reduction with two dosing regimens of latanoprost and timolol maleate in patients with primary open-angle glaucoma. American Journal of Ophthalmology .1999, 128(1):15-20.

化学性质

Cas No. 26921-17-5 SDF
别名 (S)-马来酸噻吗洛尔; L-714,465 Maleate; MK 950
化学名 (Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Canonical SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
分子式 C17H28N4O7S 分子量 432.49
溶解度 ≥ 21.6245mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3122 mL 11.561 mL 23.1219 mL
5 mM 0.4624 mL 2.3122 mL 4.6244 mL
10 mM 0.2312 mL 1.1561 mL 2.3122 mL
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