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Tioxolone Sale

(Synonyms: 噻克索酮) 目录号 : GC15158

A carbonic anhydrase I inhibitor

Tioxolone Chemical Structure

Cas No.:4991-65-5

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50mg
¥483.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Tioxolone, a metalloenzyme carbonic anhydrase I inhibitor, is an anti-acne preparation.Target: Carbonic Anhydrase Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. Tioxolone lacks sulfonamide, sulfamate, or hydroxamate functional groups that are typically found in therapeutic carbonic anhydrase (CA) inhibitors, such as acetazolamide. Tioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters. When tioxolone binds in the active site of CA II, it is cleaved and forms 4-mercaptobenzene-1,3-diol via the intermediate S-(2,4-thiophenyl) hydrogen thiocarbonate. The esterase cleavage product binds to the zinc active site via the thiol group and is therefore the active CA inhibitor, while the intermediate is located at the rim of the active-site cavity. From Wikipedia.

References:
[1]. http://en.wikipedia.org/wiki/Tioxolone

Chemical Properties

Cas No. 4991-65-5 SDF
别名 噻克索酮
化学名 6-hydroxybenzo[d][1,3]oxathiol-2-one
Canonical SMILES OC1=CC(OC(S2)=O)=C2C=C1
分子式 C7H4O3S 分子量 168.17
溶解度 ≥ 63.2 mg/mL in DMSO, ≥ 22.7 mg/mL in EtOH with ultrasonic, ≥ 2.33 mg/mL in Water with ultrasonic and warming 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.9464 mL 29.7318 mL 59.4636 mL
5 mM 1.1893 mL 5.9464 mL 11.8927 mL
10 mM 0.5946 mL 2.9732 mL 5.9464 mL
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