Tizoxanide
(Synonyms: 替唑尼特; TIZ) 目录号 : GC13915
An active metabolite of nitazoxanide
Cas No.:173903-47-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
IC50: 0.17 to 0.21 μM for CIVs
Tizoxanide is the active metabolite of nitazoxanide that is a thiazolide anti-infective drug against anaerobic bacteria, protozoa, and a range of viruses.
Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are major public health problems, causing more than an estimated 500 million chronic infections worldwide. Both HBV and HCV are a source of liver disease, and are the major risk factors for hepatocellular carcinoma.
In vitro: Previous study found that tizoxanide showed potent inhibition of both HBV and HCV replication. Tizoxanide also exhibited selective inhibition of intracellular HBV replication and extracellular virus production by 2.2.15 cells. Tizoxanide could selectively reduce intracellular HCV replication in AVA5 cells. Moreover, the combination of tizoxanide with either recombinant human interferon alpha 2b (IFNα), or an NS5B (HCV polymerase) inhibitor, 2′-C-methyl cytidine, resulted in synergistic interactions against HCV replication. In addition, antiviral activities of tizoxanide against a full-length genotype 1a replicon were equivalent to that observed for AVA5 cells [1].
In vivo: Animal study in an immunosuppressed rat model suggested that relapses were less frequent after treatment with nitazoxanide, the parent drug of tizoxanide, than with the non-absorbable sinefungin and paromomycin [2].
Clinical trial: Nitazoxanide, the parent drug of tizoxanide, is currently in phase II clinical development for treating chronic hepatitis C [1].
References:
[1] Korba BE,Montero AB,Farrar K,Gaye K,Mukerjee S,Ayers MS,Rossignol JF. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res.2008 Jan;77(1):56-63.
[2] Gargala G,Delaunay A,Li X,Brasseur P,Favennec L,Ballet JJ. Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells. J Antimicrob Chemother.2000 Jul;46(1):57-60.
| Cas No. | 173903-47-4 | SDF | |
| 别名 | 替唑尼特; TIZ | ||
| 化学名 | 2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide | ||
| Canonical SMILES | OC1=C(C=CC=C1)C(NC2=NC=C(S2)[N+]([O-])=O)=O | ||
| 分子式 | C10H7N3O4S | 分子量 | 265.25 |
| 溶解度 | ≥ 26.5mg/mL in DMSO with gentle warming | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.77 mL | 18.8501 mL | 37.7003 mL |
| 5 mM | 0.754 mL | 3.77 mL | 7.5401 mL |
| 10 mM | 0.377 mL | 1.885 mL | 3.77 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。