TM-N1324
(Synonyms: Compound 1324, Cpd1324) 目录号 : GC31074
A GPR39 agonist
Cas No.:1144477-35-9
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
TM-N1324 is an agonist of G protein-coupled receptor 39 (GPR39).1 It is selective for GPR39 over a panel of 165 GPCRs, including the growth hormone (GH) secretagogue receptor (GHS-R) and motilin receptor, at 1 ?M. TM-N1324 induces inositol phosphate accumulation in HEK293 cells expressing human GPR39 (EC50s = 2 and 201 nM in the presence and absence of zinc, respectively) and cAMP accumulation in COS-7 cells expressing human GPR39 (EC50 = 17 nM in the presence of zinc). It decreases ghrelin secretion and increases somatostatin secretion in isolated mouse gastric mucosa cells when used at a concentration of 1 ?M. TM-N1324 (30 mg/kg) decreases food intake during the dark period and body weight in a mouse model of high-fat diet-induced obesity.2
1.Frimurer, T.M., Mende, F., Graae, A.-S., et al.Model-based discovery of synthetic agonists for the Zn2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functionsJ. Med. Chem.60(3)886-898(2017) 2.Grunddal, K.V., Diep, T.A., Petersen, N., et al.Selective release of gastrointestinal hormones induced by an orally active GPR39 agonistMol. Metab.49101207(2021)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5139 mL | 12.5694 mL | 25.1389 mL |
| 5 mM | 0.5028 mL | 2.5139 mL | 5.0278 mL |
| 10 mM | 0.2514 mL | 1.2569 mL | 2.5139 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。