Tolclofos-methyl
(Synonyms: 甲基立枯磷) 目录号 : GC32167
Tolclofos-methyl是一种广谱内吸性杀菌剂,用于防治引起种子腐烂和幼苗摧残的土传和种传真菌病原体。
Cas No.:57018-04-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights.
| Cas No. | 57018-04-9 | SDF | |
| 别名 | 甲基立枯磷 | ||
| Canonical SMILES | S=P(OC)(OC1=C(Cl)C=C(C)C=C1Cl)OC | ||
| 分子式 | C9H11Cl2O3PS | 分子量 | 301.13 |
| 溶解度 | DMSO : ≥ 36 mg/mL (119.55 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3208 mL | 16.6041 mL | 33.2082 mL |
| 5 mM | 0.6642 mL | 3.3208 mL | 6.6416 mL |
| 10 mM | 0.3321 mL | 1.6604 mL | 3.3208 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Peer review of the pesticide risk assessment of the active substance Tolclofos-methyl
EFSA J 2018 Jan 29;16(1):e05130.PMID:32625677DOI:10.2903/j.efsa.2018.5130.
The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Sweden, and co-rapporteur Member State, Denmark, for the pesticide active substance Tolclofos-methyl are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of Tolclofos-methyl as a fungicide on potatoes, lettuce and ornamentals. The reliable end points, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.
Combination of chemical and toxicological methods to assess bioavailability of Tolclofos-methyl by earthworms
Chemosphere 2019 Oct;233:183-189.PMID:31173956DOI:10.1016/j.chemosphere.2019.05.215.
Tolclofos-methyl (TM) is an organophosphorus fungicide and widely utilized to control soil-borne diseases. However, toxic effects of TM on terrestrial invertebrates are still unknown. Here we measured the bioaccumulation of TM in earthworms (Eisenia fetida) to assess its environmental bioavailability. Mortality, weight change, and oxidative damage of earthworms were determined to investigate the toxicological bioavailability of TM. ROS, SOD and MDA in highest concentration treatment group significantly increased compared to the control group, suggesting that hazardous effects of TM to earthworms were caused by the oxidative stress. To further examine its toxicological bioavailability, cytotoxicity test was carried out by using extracted earthworm coelomocytes. The biomarkers, e.g., intracellular ROS, extracellular LDH, and cell viability showed correlation with TM in the culture media, demonstrating that cytotoxicity test could be employed to reflect the toxicological bioavailability of pollutants to earthworms or other organisms.
Modification of the existing maximum residue level for Tolclofos-methyl in potatoes
EFSA J 2017 Feb 22;15(2):e04730.PMID:32625417DOI:10.2903/j.efsa.2017.4730.
In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Sumitomo Chemical Agro Europe S.A.S submitted a request to the competent national authority of Finland to modify the existing maximum residue level (MRL) for the active substance Tolclofos-methyl in potatoes. The data submitted in support of the request were found to be sufficient to derive an MRL proposal of 0.2 mg/kg. An amendment of the existing MRLs for food of animal origin was not found necessary. Adequate analytical enforcement methods are available to control the residues of Tolclofos-methyl in potatoes. Based on the risk assessment results, EFSA concluded that the proposed use of Tolclofos-methyl on potatoes will not result in a consumer exposure exceeding the toxicological reference value and therefore is unlikely to pose a consumer health risk.
Evaluation of respiratory and cutaneous doses and urinary excretion of alkylphosphates by workers in greenhouses treated with omethoate, fenitrothion, and Tolclofos-methyl
AIHAJ 2001 Jan-Feb;62(1):87-95.PMID:11258873DOI:10.1080/15298660108984614.
This research evaluated exposure pathways across work tasks for three organophosphate pesticides in a group of greenhouse workers. During reentry in ornamental plant greenhouses, five male workers were monitored for five consecutive days. Skin contamination (excluding hands) was evaluated with nine pads of filter paper placed on the skin. Hand contamination was assessed by washing with 95% ethanol. Respiratory exposure was evaluated by personal air sampling. The respiratory dose was based on a lung ventilation of 20 L/min. The doses absorbed were estimated assuming 10% skin penetration and 100% lung retention. Urinary alkylphosphates were assayed in the 24-hour urine samples of the days on which exposure was evaluated. Respiratory exposure was usually less than skin contamination, being 4.5 +/- 8.4%, 9.9 +/- 10.0%, and 49.5 +/- 26.6% (mean +/- standard deviation) of total exposure for omethoate, Tolclofos-methyl, and fenitrothion, respectively. Multiple regression analysis showed that urinary alkylphosphate (nmol/24 hours) (y) was significantly correlated (r = 0.716, p < 0.001) with the respiratory doses of the three active ingredients absorbed the same day (x1) and with the cutaneous dose absorbed the previous day (x2). The relationship was expressed by the equation y = 0.592x2 + 0.117x, + 156.364. The doses of omethoate absorbed by one worker were more than 45 times the acceptable daily intake (ADI) of 1.41 nmol/kg body weight (b.w.) The ADI for fenitrothion and Tolclofos-methyl (10.8 and 212.6 nmol/kg body weight, respectively) were never exceeded. High absorption by one worker underlines the importance of correct use of protective clothing. In this study the hands were always a source of contact with the pesticides. Greater precautions should be taken to reduce contamination (clean gloves, constant use of gloves).
Reduction of the movement and persistence of pesticides in soil through common agronomic practices
Chemosphere 2011 Nov;85(8):1375-82.PMID:21872905DOI:10.1016/j.chemosphere.2011.07.063.
Laboratory and field studies were conducted in order to determine the leaching potential of eight pesticides commonly used during pepper cultivation by use of disturbed soil columns and field lysimeters, respectively. Two soils with different organic matter content (soils A and B) were used. Additionally, soil B was amended with compost (sheep manure). The tested compounds were cypermethrin, chlorpyrifos-methyl, bifenthrin, chlorpyrifos, cyfluthrin, endosulfan, malathion and Tolclofos-methyl. In soil B (lower organic matter content), only endosulfan sulphate, malathion and Tolclofos-methyl were found in leachates. For the soil A (higher organic matter content) and amended soil B, pesticide residues were not found in the leachates. In addition, this paper reports on the use of common agronomic practices (solarization and biosolarization) to enhance degradation of these pesticides from polluted soil A. The results showed that both solarization and biosolarization enhanced the degradation rates of endosulfan, bifenthrin and Tolclofos-methyl compared with the control. Most of the studied pesticides showed similar behavior under solarization and biosolarization conditions. However, chlorpyrifos was degraded to a greater extent in the solarization than in biosolarization treatment. The results obtained point to the interest in the use of organic amendment in reducing the pollution of groundwater by pesticide drainage and in the use of solarization and biosolarization in reducing the persistence of pesticides in soil.