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Tranexamic Acid-13C2,15N Sale

(Synonyms: AMCA-13C2,15N, TXA-13C2,15N) 目录号 : GC45799

An internal standard for the quantification of tranexamic acid

Tranexamic Acid-13C2,15N Chemical Structure

Cas No.:1292837-95-6

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1mg
¥6,766.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Tranexamic acid 13C2,15N is intended for use as an internal standard for the quantification of tranexamic acid by GC- or LC-MS. Tranexamic acid is an inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 μM in isolated human plasma).1 It reduces increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfβ1, or Tgfβ2, and increases in hepatic protein levels of cytokeratin 19 (CK19) and type I collagen induced by α-naphthylisothiocyanate (AINT) after 28 days in a mouse model of chronic bile duct injury.2

|1. Bostr•m, J., Grant, J.A., Fjellstr•m, O., et al. Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid. J. Med. Chem. 56(8), 3273-3280 (2013).|2. Joshi, N., Kopec, A.K., Towery, K., et al. The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J. Pharmacol. Exp. Ther. 349(3), 383-392 (2014).

Chemical Properties

Cas No. 1292837-95-6 SDF
别名 AMCA-13C2,15N, TXA-13C2,15N
Canonical SMILES O[13C]([C@H]1CC[C@H]([13CH2][15NH2])CC1)=O
分子式 C6[13C2]H15[15N]O2 分子量 160.2
溶解度 Water: slightly soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 6.2422 mL 31.211 mL 62.422 mL
5 mM 1.2484 mL 6.2422 mL 12.4844 mL
10 mM 0.6242 mL 3.1211 mL 6.2422 mL
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